{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:33:18Z","timestamp":1790353998499,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Medical Sciences research program of Dalian of China","award":["1812033"],"award-info":[{"award-number":["1812033"]}]},{"name":"Natural Science Foundation of Liaoning Province of China","award":["20180550865"],"award-info":[{"award-number":["20180550865"]}]},{"name":"The Basic Research Program of Higher Education of Liaoning Province of China","award":["LQ2017027"],"award-info":[{"award-number":["LQ2017027"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Costunolide, a sesquiterpene lactone, a small molecular monomer extracted from <jats:styled-content style=\"fixed-case\"><jats:italic>Inula helenium<\/jats:italic><\/jats:styled-content>, has been reported to possess antiproliferative effects on several cancer cell lines. The current study was designed to evaluate the effect of costunolide on sensitivity of K562\/ADR chronic myeloid leukemia cells to doxorubicin. The antiproliferative effect of costunolide was assessed by CCK\u20108 assay. Flow cytometry and Western blot were used to examine the mechanisms of antileukemia action. Costunolide dramatically enhanced doxorubicin\u2010induced antiproliferative activity against K562\/ADR cells through inhibition of PI3K\/Akt pathway, activation of caspases 3, cleavage of poly (ADP\u2010ribose) polymerase, and downregulation of p\u2010glycoprotein expression. These results demonstrate that costunolide may be a potent therapeutic agent against CML.<\/jats:p>","DOI":"10.1002\/ptr.6355","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T03:01:19Z","timestamp":1554174079000},"page":"1683-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Costunolide enhances sensitivity of K562\/ADR chronic myeloid leukemia cells to doxorubicin through PI3K\/Akt pathway"],"prefix":"10.1002","volume":"33","author":[{"given":"Hong","family":"Cai","sequence":"first","affiliation":[{"name":"Clinical Laboratory The Second Hospital of Dalian Medical University  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Laboratory The Second Hospital of Dalian Medical University  Dalian 116023 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