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Much effort has been expended to explore the pathogenesis of ALD. Hepatic cell injury, oxidative stress, inflammation, regeneration, and bacterial translocation are all involved in the pathogenesis of ALD. Immediate abstinence is the most important therapeutic treatment for affected individuals. However, the medical treatment for ALD had not advanced in a long period. Intriguingly, an increasing body of research indicates the potential of natural compounds in the targeted therapy of ALD. A plethora of dietary natural products such as flavonoids, resveratrol, saponins, and \u03b2\u2010carotene are found to exert protective effects on ALD. This occurs through various mechanisms composed of antioxidative, anti\u2010inflammatory, iron chelation, pro\u2010apoptosis, and\/or antiproliferation of hepatic stellate cells and hepatocellular carcinoma cells. In this review, we will summarize current knowledge about the pathogenesis and treatments of ALD and focus on the potential of natural compounds in ALD therapies and underlying mechanisms.<\/jats:p>","DOI":"10.1002\/ptr.6410","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T09:00:28Z","timestamp":1562058028000},"page":"2192-2212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Natural compounds in the chemoprevention of alcoholic liver disease"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-127X","authenticated-orcid":false,"given":"Yingfeng","family":"Tu","sequence":"first","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Science and Technology for Development, Ministry of Science and Technology Institute of Foresight and Evaluation Research  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Burstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas  Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-1998","authenticated-orcid":false,"given":"Da","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"306","article-title":"Neuroprotective and hepatoprotective effects of micronized purified flavonoid fraction (Daflon\u00ae) in lipopolysaccharide\u2010treated rats","volume":"6","author":"Abdel\u2010Salam O. 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