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The MS is one of the most important health concerns in industrialized countries and mainly results from a sedentary lifestyle, high levels of subjective stress, and unhealthy diets. Nowadays, the identification of appropriate health care approaches, such as herbal medicines, with fewer side effects is more favorable, especially with regard to the adverse effects of chemical drugs. <jats:italic>Aloe barbadensis<\/jats:italic> Miller known as <jats:italic>Aloe vera<\/jats:italic> is a useful plant with two major parts, including leaves that contain high concentrations of anthraquinone compounds and a clear gel. The gel is used as a food with several beneficial properties, such as antiinflammatory, antioxidant, antiviral, antibacterial, and wound\u2010healing features. Other effects of <jats:italic>A<\/jats:italic>. <jats:italic>vera<\/jats:italic>, such as its lipid\u2010lowering, antihypertensive, antidiabetic, antiobesity, and cardioprotective impacts, have been demonstrated in several studies. The present study was conducted to review the evidence on the pharmacological effects of <jats:italic>A<\/jats:italic>. <jats:italic>vera<\/jats:italic> on the different components of MS.<\/jats:p>","DOI":"10.1002\/ptr.6465","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T08:18:48Z","timestamp":1566980328000},"page":"2649-2660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["<i>Aloe vera<\/i> as an herbal medicine in the treatment of metabolic syndrome: A review"],"prefix":"10.1002","volume":"33","author":[{"given":"Zahra","family":"Shakib","sequence":"first","affiliation":[{"name":"School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naghmeh","family":"Shahraki","sequence":"additional","affiliation":[{"name":"School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi Marjan","family":"Razavi","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-851X","authenticated-orcid":false,"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-86"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5570"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S67400"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0137-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.04.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2018.1449159"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500600614303"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-013-9323-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.02.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1543-1150(03)00005-X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-011-0459-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316665729"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328042ba90"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2012.0066"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790112620"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.1137-1139.2003"},{"key":"e_1_2_10_20_1","first-page":"809","article-title":"Plants with potential use on obesity and its complications","volume":"14","author":"Gamboa\u2010Gomez C. 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