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The pharmacological potential and unique skeleton types of certain<jats:italic>Artemisia<\/jats:italic>'s alkaloids provoke the importance of analyzing<jats:italic>Artemisia<\/jats:italic>species for bioactive alkaloids and allied nitrogen compounds. Among the various types of bioactive<jats:italic>Artemisia<\/jats:italic>'s alkaloids, the main classes were the derivatives of rupestine (pyridine\u2013sesquiterpene), lycoctonine (diterpene), pyrrolizidine, purines, polyamine, peptides, indole, piperidine, pyrrolidine, alkamides, and flavoalkaloids. The rupestine derivatives are<jats:italic>Artemisia<\/jats:italic>'s characteristic alkaloids, whereas the rest are common alkaloids found in the family Asteraceae and chemotaxonomically links the genus<jats:italic>Artemisia<\/jats:italic>with the tribes Anthemideae. The most important biological activities of<jats:italic>Artemisia<\/jats:italic>'s alkaloids are including hepatoprotective, local anesthetic,<jats:italic>\u03b2<\/jats:italic>\u2010galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep\u2010inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]\u2010AEA metabolism, kinases, and DNA polymerase<jats:italic>\u03b2<\/jats:italic><jats:sup>1<\/jats:sup>. Some of the important nitrogen metabolites of<jats:italic>Artemisia<\/jats:italic>include pellitorine, zeatin, tryptophan, rupestine, and aconitine analogs, which need to be optimized and commercialized further.<\/jats:p>","DOI":"10.1002\/ptr.6466","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T09:34:46Z","timestamp":1566898486000},"page":"2661-2684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The chemistry and pharmacology of alkaloids and allied nitrogen compounds from<i>Artemisia<\/i>species: A review"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-8958","authenticated-orcid":false,"given":"Mamoon","family":"Ur Rashid","sequence":"first","affiliation":[{"name":"Department for Management of Science and Technology Development Ton Duc Thang University Ho Chi Minh City Vietnam"},{"name":"Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Alamzeb","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Kotli Kotli Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Kotli Kotli Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahoor","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Chemistry Balochistan University of IT, Engineering and Management Sciences Quetta Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Agriculture Chemistry Agriculture University Peshawar Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishrat","family":"Naz","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology Agriculture University Peshawar Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rafiullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Phytopharmaceutical and Nutraceutical Research Laboratory (PNRL), Institute of Chemical Sciences University of Peshawar Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17032542"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph5101045"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-008-0064-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.03.032"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-1483.80300"},{"issue":"2","key":"e_1_2_5_8_1","first-page":"88","article-title":"The pharmacological importance of Artemisia campestris\u2014A review","volume":"5","author":"Al\u2010Snafi A. 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