{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:54:10Z","timestamp":1790268850481,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Discipline Group Construction Project of Shanghai Pudong","award":["PWZxq2017-02"],"award-info":[{"award-number":["PWZxq2017-02"]}]},{"name":"Featured Clinical Discipline Project of Shanghai Pudong","award":["PWYst2018-01"],"award-info":[{"award-number":["PWYst2018-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Neuroinflammation and oxidative stress are key contributors to intracranial hemorrhage (ICH)\u2010induced brain injury. Parthenolide (PN) is a sesquiterpene lactone that has been observed to have antioxidative, anti\u2010inflammatory, and neuroprotective potentials. However, the role of PN in ICH remains unclear. Therefore, we investigated the neuroprotective effects and underlying mechanisms of PN on an experimental model of ICH in rats. Our results showed that PN treatment improved neurological deficit and brain edema in ICH rats. The ipsilateral hemispheres of the brain were separated and homogenized. The concentrations of TNF\u2010\u03b1, interleukin (IL)\u20106, and IL\u201017 in the homogenates were detected by enzyme\u2010linked immunosorbent assay. We found that PN inhibited the production of proinflammatory cytokines in an ICH rat model. The ROS and glutathione (GSH) levels, as well as the activity of superoxide dismutase (SOD) in the homogenates were measured. ICH caused an increase in ROS level, and the decreases in GSH level and SOD activity were mitigated by PN treatment. Furthermore, PN significantly suppressed the expressions of active caspase\u20103 and Bax in ipsilateral hemispheres of the brain at Day 3 after ICH, as well as increased the surviving neurons. Finally, the ICH\u2010induced activation of TLR4\/NF\u2010\u03baB pathway was suppressed by PN treatment. These findings suggested that PN could be beneficial in the therapeutic strategy for ICH treatment.<\/jats:p>","DOI":"10.1002\/ptr.6510","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T09:17:51Z","timestamp":1568020671000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Parthenolide ameliorates intracerebral hemorrhage\u2010induced brain injury in rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Jun\u2010an","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences  Shanghai China"},{"name":"Department of Anesthesiology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010liang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Central Hospital of Minhang District  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010hua","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-6634","authenticated-orcid":false,"given":"Jian\u2010ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596718"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.2619"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/370804"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1203285"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.05.063"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.06.045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000069"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9460462"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.10.025"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2014.938113"},{"key":"e_1_2_7_14_1","first-page":"8369","article-title":"Parthenolide inhibits hydrogen peroxideinduced osteoblast apoptosis","volume":"17","author":"Mao W.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00388"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-015-1132-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/676473"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2322-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.12.009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.09.022"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5135429"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.120"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400889"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401360"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.981541"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.035"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2179-y"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"70669","DOI":"10.18632\/oncotarget.19974","article-title":"MicroRNA\u201027b inhibition promotes Nrf2\/ARE pathway activation and alleviates intracerebral hemorrhage\u2010induced brain injury","volume":"842","author":"Xu W.","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000662"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6510","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T02:35:45Z","timestamp":1694140545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/ptr.6510"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6510","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]},"assertion":[{"value":"2019-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}