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Therefore, MRGPRX2 might be a therapeutic target for allergic contact dermatitis, atopic dermatitis, and red man syndrome. Paeoniflorin (PF) was reported to have an antiinflammatory effect in neuroinflammation, enteritis, and so forth. In this study, we investigated the anti\u2010pseudo\u2010allergic effect of PF and the underlying molecular mechanisms. Our results showed that PF can suppress compound 48\/80 (C48\/80)\u2010induced PCA and MCs degranulation <jats:italic>in vivo<\/jats:italic>, in a dose\u2010dependent manner. Moreover, PF can reduce C48\/80\u2010induced calcium influx and suppress MC degranulation and chemokines release <jats:italic>in vitro<\/jats:italic>. PF can downregulate the phosphorylation levels of key kinases in PLC\u03b3\u2010regulated calcium influx and subsequent cytokine synthesis pathways. Our study revealed that PF could inhibit C48\/80\u2010induced allergic responses both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. As such, it may be regarded as a novel inhibitor for preventing MRGPRX2\u2010mediated allergic diseases.<\/jats:p>","DOI":"10.1002\/ptr.6531","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T08:46:23Z","timestamp":1572511583000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Paeoniflorin inhibits MRGPRX2\u2010mediated pseudo\u2010allergic reaction via calcium signaling pathway"],"prefix":"10.1002","volume":"34","author":[{"given":"Jianli","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an China"},{"name":"Research and Development Center Tianjin Chasesun Pharmaceutical Co., Ltd  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University  Xi'an 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