{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:15:54Z","timestamp":1767136554502,"version":"build-2238731810"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n                    Type 1 diabetes mellitus (T1DM) is a systemic disease and one classical type of total DM. Bilobalide (BB) is constituted of EGb 761. Our purpose was identifying the role of BB in TIDM in the current study. MIN6 cells were treated by TNF\u2010\u03b1; then, viability, apoptosis, and insulin secretion were assessed by performing Cell Counting Kit\u20108 assay, flow cytometry, glucose\u2010stimulated insulin secretion assay, and western blot. The effects of BB were assessed to identify its function. Further, the above mentioned parameters were reassessed when silencing miR\u2010153. TNF\u2010\u03b1 declined viability and insulin secretion as well as raised apoptosis and inducible\n                    <jats:italic>nitric oxide synthase (<\/jats:italic>\n                    iNOS) expression in MIN6 cells. BB alleviated the apoptosis and dysfunction induced by TNF\u2010\u03b1. MiR\u2010153 expression was elevated by BB when induced by TNF\u2010\u03b1. Increase of viability and insulin secretion as well as decline of apoptosis and iNOS induced by BB treatment was alleviated by silencing miR\u2010153. The rates of p\/t\u2010p70S6K, p\/t\u2010mammalian target of rapamycin (mTOR) and p\/t\u2010adenosine monophosphate\u2010activated protein kinase (AMPK) were raised by BB and suppressed by silencing miR\u2010153 under TNF\u2010\u03b1 induced condition. BB raised viability and insulin secretion, declined apoptosis and iNOS expression by up\u2010regulating miR\u2010153. Furthermore, BB activated AMPK\/mTOR pathway by up\u2010regulating miR\u2010153.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6533","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T03:45:22Z","timestamp":1572493522000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retracted: Bilobalide alleviates tumor necrosis factor\u2010alpha\u2010induced pancreatic beta\u2010cell MIN6 apoptosis and dysfunction through upregulation of miR\u2010153"],"prefix":"10.1002","volume":"34","author":[{"given":"Yan","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Endocrinology Jining No.1 People's Hospital  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jining No.1 People's Hospital  Jining 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