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In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as<jats:italic>Mangifera indica<\/jats:italic>L. Previous studies have documented its analgesic, anti\u2010inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.<\/jats:p>","DOI":"10.1002\/ptr.6546","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T08:06:07Z","timestamp":1574409967000},"page":"505-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain"],"prefix":"10.1002","volume":"34","author":[{"given":"B\u00e1rbara B.","family":"Garrido\u2010Su\u00e1rez","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda y Toxicolog\u00eda Centro de Investigaci\u00f3n y Desarrollo de Medicamentos Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-4109","authenticated-orcid":false,"given":"Gabino","family":"Garrido","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Universidad Cat\u00f3lica del Norte Antofagasta Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Pi\u00f1eros","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Universidad de Santiago de Cali Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Delgado\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Estudio para las Investigaciones y Evaluaciones Biol\u00f3gicas, Instituto de Farmacia y Alimentos Universidad de La Habana Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00162-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-001-0069-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.02.017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04680.2000"},{"key":"e_1_2_12_6_1","first-page":"1102","article-title":"Osteoarthritis and sleep: The Johnston Country Osteoarthritis Project","volume":"35","author":"Allen K. 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