{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:56:16Z","timestamp":1790898976949,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    Many developed countries are experiencing a rapidly \u201cgreying\u201d population, and cognitive decline is common in the elderly. There is no cure for dementia, and pharmacotherapy options to treat cognitive dysfunction provide limited symptomatic improvements.\n                    <jats:italic>Withania somnifera<\/jats:italic>\n                    (Ashwagandha), a popular herb highly valued in Ayurvedic medicine, has often been used to aid memory and cognition. This systematic review thus aimed to evaluate the clinical evidence base and investigate the potential role of\n                    <jats:italic>W. somnifera<\/jats:italic>\n                    in managing cognitive dysfunction. Using the following keywords [withania somnifera OR indian ginseng OR Ashwagandha OR winter cherry] AND [brain OR cognit* OR mental OR dementia OR memory], a comprehensive search of PubMed, EMBASE, Medline, PsycINFO and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                    databases found five clinical studies that met the study's eligibility criteria. Overall, there is some early clinical evidence, in the form of randomized, placebo\u2010controlled, double\u2010blind trials, to support the cognitive benefits of\n                    <jats:italic>W. somnifera<\/jats:italic>\n                    supplementation. However, a rather heterogeneous study population was sampled, including older adults with mild cognitive impairment and adults with schizophrenia, schizoaffective disorder, or bipolar disorder. In most instances,\n                    <jats:italic>W. somnifera<\/jats:italic>\n                    extract improved performance on cognitive tasks, executive function, attention, and reaction time. It also appears to be well tolerated, with good adherence and minimal side effects.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6552","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T13:35:36Z","timestamp":1574170536000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["A systematic review of the clinical use of\n                    <i>Withania somnifera<\/i>\n                    (Ashwagandha) to ameliorate cognitive dysfunction"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-2513","authenticated-orcid":false,"given":"Qin Xiang","family":"Ng","sequence":"first","affiliation":[{"name":"MOH Holdings Pte Ltd.  1 Maritime Square 099253 Singapore Singapore"},{"name":"Institute of Mental Health  10 Buangkok View 539747 Singapore 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Wuen","family":"Chan","sequence":"additional","affiliation":[{"name":"National University Hospital National University Health System  119074 Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  117597 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan Yutong","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Mental Health  10 Buangkok View 539747 Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  117597 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Song","family":"Yeo","sequence":"additional","affiliation":[{"name":"National University Hospital National University Health System  119074 Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  117597 Singapore 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