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Curcumin has shown potential antidepressant\u2010like activities in some studies. The present study is the first randomized controlled trial to test the efficacy of nano\u2010curcumin supplementation on depression, anxiety, and stress in patients with diabetic polyneuropathy. Eighty patients with diabetes were enrolled in this parallel, double\u2010blind, randomized, placebo\u2010controlled clinical trial. The participants were allocated randomly to the intervention (<jats:italic>n<\/jats:italic> = 40) and control (<jats:italic>n<\/jats:italic> = 40) groups. They received 80 mg of nano\u2010curcumin or placebo capsules daily for 8 weeks. At baseline and end of study, anthropometric measurements, dietary intake, physical activity, glycemic indices, and severity of neuropathy were assessed. The depression, anxiety, and stress level were measured by Depression, Anxiety, Stress Scale (DASS\u201021\u2010items) questionnaire before and after the intervention. After intervention, there was a significant reduction in the mean score of depression in the nano\u2010curcumin group (from 16.7 [3.1] to 15.3 [2.6]) compared with placebo group (17.5 [3.2] to 17.3 [3.1]; <jats:italic>p<\/jats:italic> = .02). In addition, a significant fall was found in the mean score of anxiety in the nano\u2010curcumin group (from 22.4 [4.03] to 20.6 [3.4]) compared with the placebo group (21.9 [3.5] to 21.2 [3.5]; <jats:italic>p<\/jats:italic> = .009). Changes in stress score were not statistically significant between the two groups. These findings suggested that nano\u2010curcumin supplementation for 8 weeks was effective in reducing depression and anxiety scores in patients with diabetic polyneuropathy.<\/jats:p>","DOI":"10.1002\/ptr.6571","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T20:06:29Z","timestamp":1575317189000},"page":"896-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Beneficial effects of nano\u2010curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double\u2010blind, placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"34","author":[{"given":"Sara","family":"Asadi","sequence":"first","affiliation":[{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Saeed","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Medicine Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereydoun","family":"Siassi","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Qorbani","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"},{"name":"Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-2581","authenticated-orcid":false,"given":"Gity","family":"Sotoudeh","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.02.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.03.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3458-05.2005"},{"key":"e_1_2_7_5_1","unstructured":"Bostani A.andHomayounfarH. 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