{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:00:04Z","timestamp":1768006804736,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"The seeds of Sophora alopecuroides<\/jats:italic> L. var. alopecuroides<\/jats:italic> (S. alopecuroides<\/jats:italic><\/jats:styled-content>) have alleviated morphine withdrawal in mice. Therefore, in this study, the alkaloid composition of S. alopecuroides<\/jats:italic><\/jats:styled-content> extract was determined by gas chromatography (GC) and gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis. Moreover, 50 abstinent opium addicts consumed three 400 mg extract capsules once daily and 50 other patients took placebo for 8 days. At the baseline and days 3 and 8, the clinical opiate withdrawal scale (COWS) was used to assess withdrawal symptoms. At the baseline and Day 8, the patients' blood levels of serum glutamate oxaloacetate transferase; serum glutamate pyruvate transferase; alkaline phosphatase; total, direct, and indirect bilirubins; creatinine and blood urea nitrogen; complete blood count; and prothrombine time were measured. The groups' parameter values were also compared. Sophocarpine, matrine, and sophoramine were the major alkaloids constituting, respectively, 32.85, 26.55, and 6.91% of the extract. The extract decreased the COWS score at Days 3 and 8 significantly compared with the placebo (p<\/jats:italic> < .001). The extract did not significantly affect the blood parameters' values compared with the placebo (p<\/jats:italic> > .05). There was no adverse drug effect. In conclusion, the extract reduces the acute opioid withdrawal symptoms and seems to have good safety and tolerability.<\/jats:p>","DOI":"10.1002\/ptr.6578","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T11:44:41Z","timestamp":1575373481000},"page":"1108-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of Sophora alopecuroides<\/i> var. alopecuroides<\/i> seed extract for opioid detoxification: A randomized, double\u2010blind, and placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-248X","authenticated-orcid":false,"given":"Saeed","family":"Kianbakht","sequence":"first","affiliation":[{"name":"Medicinal Plants Research Center Institute of Medicinal Plants, ACECR Karaj 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