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H\n                    <jats:sub>2<\/jats:sub>\n                    S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H\n                    <jats:sub>2<\/jats:sub>\n                    S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC\u20101 cells growth. DATS treatment triggered a rapid H\n                    <jats:sub>2<\/jats:sub>\n                    S generation within 5 min in KTC\u20101 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H\n                    <jats:sub>2<\/jats:sub>\n                    S contributed to the apoptosis\u2010inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma\u2010lyase (CTH), one of H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing enzymes, which was responsible for endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S generation. After DATS treatment, H\n                    <jats:sub>2<\/jats:sub>\n                    S quickly permeated cell membranes and activated NF\u2010\u03ba\u0392\/p65 signaling pathway in KTC\u20101 cells. Nuclear translocated NF\u2010\u03baB bound to the promoter of\n                    <jats:italic>CTH<\/jats:italic>\n                    to enhance its transcription. These evidences proved that exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S. This positive feedback sustained excess H\n                    <jats:sub>2<\/jats:sub>\n                    S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010based antitumor agents.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6586","type":"journal-article","created":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T20:35:08Z","timestamp":1580070908000},"page":"1154-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diallyl trisulfide, a H\n                    <sub>2<\/sub>\n                    S donor, inhibits cell growth of human papillary thyroid carcinoma KTC\u20101 cells through a positive feedback loop between H\n                    <sub>2<\/sub>\n                    S and cystathionine\u2010gamma\u2010lyase"],"prefix":"10.1002","volume":"34","author":[{"given":"Shichen","family":"Xu","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Cheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangxia","family":"Zheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine  Wuxi China"},{"name":"School of Food Science and Technology Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; 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