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Flavonoids are regarded as the most common active components in TCMs because of their beneficial functions in the brain and erythropoietic system. Erythropoietin (EPO), a glycoprotein hormone, has been well\u2010studied for its neuroprotective function. The blood circulating EPO is not able to cross the blood brain barrier, and thus there is mounting demand to search for compounds that can induce endogenous cerebral EPO. Here, tectorigenin, an active compound in the rhizome of <jats:styled-content style=\"fixed-case\"><jats:italic>Belamcanda chinensis<\/jats:italic><\/jats:styled-content> (L.) DC., significantly induced the expression of EPO mRNA via accumulation of hypoxia\u2010inducible factor (HIF)\u20101\u03b1 in cultured neuron\u2010like NT2\/D1 cells and rat cortical neurons. Furthermore, tectorigenin induced transcription of HIF\u20101\u03b1 and reduced degradation of HIF\u20101\u03b1\u2010OH, a hydroxylated form of HIF\u20101\u03b1, in the culture. Thus, the upregulation of HIF\u20101\u03b1 was assumed to play a significant role in regulating EPO during the treatment of tectorigenin in cultured neurons. Hence, we reported the neuroprotective function of tectorigenin through upregulation of EPO in neurons, which could be a good candidate in developing drugs or food supplements for the treatment of brain disorders.<\/jats:p>","DOI":"10.1002\/ptr.6599","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T08:01:00Z","timestamp":1576569660000},"page":"1329-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tectorigenin, an isoflavone aglycone from the rhizome of <i>Belamcanda chinensis<\/i>, induces neuronal expression of erythropoietin via accumulation of hypoxia\u2010inducible factor\u20101\u03b1"],"prefix":"10.1002","volume":"34","author":[{"given":"Etta Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science South China Agricultural University  Guangzhou China"},{"name":"Shenzhen Key Laboratory of Edible and Medicinal Bioresources SRI, The Hong Kong University of Science and Technology Shenzhen  Shenzhen China"},{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoey X.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brody Z.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Edible and Medicinal Bioresources SRI, The Hong Kong University of Science and Technology Shenzhen  Shenzhen China"},{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Xia","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Edible and Medicinal Bioresources SRI, The Hong Kong University of Science and Technology Shenzhen  Shenzhen China"},{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie S.","family":"Guo","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Edible and Medicinal Bioresources SRI, The Hong Kong University of Science and Technology Shenzhen  Shenzhen China"},{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina T.","family":"Dong","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Edible and Medicinal Bioresources SRI, The Hong Kong University of Science and Technology Shenzhen  Shenzhen China"},{"name":"Division of Life Science, Center for Chinese Medicine The Hong Kong University of Science and Technology  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-1674","authenticated-orcid":false,"given":"Karl W. 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