{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:02:35Z","timestamp":1773446555732,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["95\u201001\u201084\u201013771"],"award-info":[{"award-number":["95\u201001\u201084\u201013771"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>The aim of this study was to evaluate the effects of <jats:styled-content style=\"fixed-case\"><jats:italic>Nigella sativa<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>N. sativa<\/jats:italic><\/jats:styled-content>) in addition to quadruple\u2010therapy on <jats:italic>Helicobacter pylori<\/jats:italic> eradication, dyspepsia, biochemical\u2010markers, and quality of life in infected patients. In this double\u2010blind placebo\u2010controlled clinical\u2010trial, 51 <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> infected patients with functional dyspepsia were randomly assigned to treatment (quadruple\u2010therapy with 2 g\/day <jats:styled-content style=\"fixed-case\"><jats:italic>N. sativa<\/jats:italic><\/jats:styled-content>) or placebo groups (quadruple\u2010therapy with 2\u2009g\/day placebo) for 8\u2009weeks. Serum levels of interleukin\u20108 (IL\u20108), high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and malondialdehyde, quality of life, dyspepsia, food\u2010intake, body\u2010weight, and body mass index (BMI) were evaluated at the baseline and at the end of the study. <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication was evaluated at the end of the intervention. At the end of the study, <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication was more in the <jats:styled-content style=\"fixed-case\"><jats:italic>N. sativa<\/jats:italic><\/jats:styled-content> group compared with the placebo (<jats:italic>p<\/jats:italic> = .01). Weight, BMI, and dietary\u2010intake (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) increased significantly as compared with placebo. A significant improvement was also observed in patients' quality of life in the treatment group compared with the placebo (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The differences of biochemical\u2010markers and dyspepsia between the two groups were not significant. So, <jats:styled-content style=\"fixed-case\"><jats:italic>N. sativa<\/jats:italic><\/jats:styled-content> supplementation with medical treatment may have beneficial effects on <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> eradication, weight, BMI, dietary\u2010intake, and quality of life in infected patients.<\/jats:p>","DOI":"10.1002\/ptr.6610","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T11:55:29Z","timestamp":1578570929000},"page":"1367-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The beneficial health effects of <scp><i>Nigella sativa<\/i><\/scp> on <i>Helicobacter pylori<\/i> eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot 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