{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:46:31Z","timestamp":1792291591528,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nutrilinea srl"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>to evaluate if a nutraceutical compound containing <jats:styled-content style=\"fixed-case\"><jats:italic>Ilex paraguariensis<\/jats:italic><\/jats:styled-content>, White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre\u2010diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>we enrolled patients with IFG or IGT, not taking other hypoglycemic compounds. Patients were randomized to take placebo or the nutraceutical compound for 3\u2009months, in a randomized, double\u2010blind, placebo\u2010controlled design. Both treatments were self\u2010administered once a day, 1 tablet during the breakfast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>a reduction of FPG was observed with the nutraceutical combination (\u22127.8%). Furthermore, there was a decrease of HOMA\u2010IR with the nutraceutical combination (\u22127.9%). M value was higher (<jats:italic>p<\/jats:italic> &lt;\u20090.05 vs baseline and p\u2009&lt;\u20090.05 vs placebo) at the end of the treatment. We obtained a reduction of Tg with the nutraceutical combination (\u22128.3%). About 16.6% of patients treated with nutraceutical returned to have a normal glycemia (&lt;\u2009100\u2009mg\/dL), and all patients had an improvement of insulin\u2010resistance, in particular 67% of patients returned to have a M value inside range of normal insulin sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>a nutraceutical containing <jats:styled-content style=\"fixed-case\"><jats:italic>Ilex paraguariensis<\/jats:italic><\/jats:styled-content>, White Mulberry and Chromium Picolinate at 500\u2009mg can be helpful in improving glycemia and Tg value, in patients with pre\u2010diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ptr.6611","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T02:15:16Z","timestamp":1580264116000},"page":"1377-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp><i>Ilex paraguariensis<\/i><\/scp>, white mulberry and chromium picolinate in patients with pre\u2010diabetes"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-4760","authenticated-orcid":false,"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics University of Pavia and Fondazione IRCCS Policlinico San Matteo  PAVIA Italy"},{"name":"Laboratory of Molecular Medicine University of Pavia  PAVIA Italy"},{"name":"Centre for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases Fondazione IRCCS Policlinico San Matteo  PAVIA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics University of Pavia and Fondazione IRCCS Policlinico San Matteo  PAVIA Italy"},{"name":"Laboratory of Molecular Medicine University of Pavia  PAVIA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Maffioli","sequence":"additional","affiliation":[{"name":"Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics University of Pavia and Fondazione IRCCS Policlinico San Matteo  PAVIA Italy"},{"name":"Centre for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases Fondazione IRCCS Policlinico San Matteo  PAVIA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.1.148"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"S184","article-title":"Standards of medical Care in Diabetes","volume":"42","author":"American Diabetes Association","year":"2019","journal-title":"Diabetes Care"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.01.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00101.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9904517"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.06.039"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901660g"},{"key":"e_1_2_8_11_1","first-page":"40","article-title":"The cardiometabolic risk: A new concept for old diseases","volume":"1","author":"Derosa G.","year":"2019","journal-title":"Nutrafoods"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00166.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(00)80024-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532005000500007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.01.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103182"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2007.00535.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01225569"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985847"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4803"},{"key":"e_1_2_8_22_1","first-page":"8983232","article-title":"Evaluation of a Standardized Extract from Morus alba against \u03b1\u2010Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double\u2010Blind Clinical Trial","author":"Hwang S. 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