{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:00:12Z","timestamp":1778731212444,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Curcumin (CUR) is a kind of polyphenolic compound and widely used in the treatment of diseases. However, the involvement of CUR in thymic carcinoma remains unknown. The object of our research is to clarify the role of CUR and related regulatory mechanism in thymic carcinoma cells. After treatment with CUR for 24\u2009hr, cell viability, apoptosis, migration, and invasion of TC1889 cells were measured. Real\u2010time polymerase chain reaction was executed to examine the expression of microRNA\u201027a (miR\u201027a) in thymic carcinoma tissues and TC1889 cells. After miR\u201027a mimic transfection, whether miR\u201027a is involved in CUR\u2010modulated cell behaviors was measured. Finally, western blot was utilized to detect mTOR and Notch 1 pathways\u2010linked proteins. CUR restrained cell viability and increased cell apoptosis of TC1889 cells. In addition, cell migration and invasion were restrained by CUR. Meanwhile, miR\u201027a expression was positively regulated in thymic carcinoma tissues and downregulated by CUR in TC1889 cells. Overexpressed miR\u201027a reversed the CUR\u2010induced reduction of growth, migration, and invasion in TC1889 cells. Furthermore, CUR blocked mTOR and Notch 1 pathways via downregulating miR\u201027a. We demonstrated that CUR blocked mTOR and Notch 1 pathways via downregulating miR\u201027a, thereby suppressing cell growth, migration, and invasion of thymic carcinoma cells.<\/jats:p>","DOI":"10.1002\/ptr.6629","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T07:50:26Z","timestamp":1582012226000},"page":"1629-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Curcumin inhibits cell viability, migration, and invasion of thymic carcinoma cells via downregulation of microRNA\u201027a"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhifeng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery China\u2010Japan Union Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics 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