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While research regarding the treatment of certain diseases\/disorders with cannabis and cannabinoids is also expanding, only a few longitudinal studies have assessed the mid\u2010term impacts of medical cannabis use on psychological variables and quality of life (QoL). The aim of the study was to assess the psychological safety and QoL of patients with chronic diseases who self\u2010medicate with cannabis over time. We recruited patients with various chronic diseases who use cannabis and collected data regarding patterns of cannabis use as well as mental health, personality and QoL. Participants were followed\u2010up at baseline, 4, 8 and 12\u2009months. Hair analysis was conducted to confirm the presence of cannabinoids. Personality assessment showed a consistent decrease in self\u2010transcendence and self\u2010directedness scores. Neither cognitive nor psychopathological deterioration was found. There were also no variations in QoL. Mid\u2010term use of medical cannabis seems to show adequate tolerability regarding cognitive and psychopathological abilities, and it may help patients with chronic diseases to maintain an acceptable QoL.<\/jats:p>","DOI":"10.1002\/ptr.6639","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T16:29:05Z","timestamp":1582302545000},"page":"1670-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quality of Life, Mental Health, Personality and Patterns of Use in Self\u2010Medicated Cannabis Users with Chronic Diseases: A 12\u2010Month Longitudinal Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Jos\u00e9 C.","family":"Bouso","sequence":"first","affiliation":[{"name":"ICEERS\u2014International Center for Ethnobotanical Education, Research and Service  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jim\u00e9nez\u2010Garrido","sequence":"additional","affiliation":[{"name":"ICEERS\u2014International Center for Ethnobotanical Education, Research and Service  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen\u00eds","family":"Ona","sequence":"additional","affiliation":[{"name":"ICEERS\u2014International Center for Ethnobotanical Education, Research and Service  Barcelona Spain"},{"name":"Department of Anthropology, Philosophy and Social Work Universitat Rovira i Virgili, Medical Anthropology Research Center  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Wo\u017anica","sequence":"additional","affiliation":[{"name":"ICEERS\u2014International Center for Ethnobotanical Education, Research and Service  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael G.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"ICEERS\u2014International Center for Ethnobotanical Education, Research and Service  Barcelona Spain"},{"name":"Department of Neurosciences and Behavior University of S\u00e3o Paulo  Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"},{"name":"National Institute for Translational Medicine (INCT\u2010TM) CNPq  Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime E.C.","family":"Hallak","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavior University of S\u00e3o Paulo  Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"},{"name":"National Institute for Translational Medicine (INCT\u2010TM) CNPq  Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz A. 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