{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:09:15Z","timestamp":1780668555613,"version":"3.54.1"},"reference-count":68,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CONICYT PIA\/APOYO CCTE","award":["AFB170007"],"award-info":[{"award-number":["AFB170007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Schistosoma mansoni<\/jats:italic><\/jats:styled-content> is endemic in 55 countries around the world. <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic><\/jats:styled-content> is a water\u2010borne parasite of humans belonging to the group of blood flukes. Generally, schistosomiasis is treated with praziquantel, which results in frequent treatment failures and reinfections. Essential oils have diverse biological effects, including antimicrobial, antiprotozoal and antiparasitic. This review aimed at summarizing available in vitro, in vivo and clinical trials showing evidence and mechanisms of actions of essential oils and their derivatives acting against <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic><\/jats:styled-content>. The findings suggest that a number of essential oils and\/or their components act against <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic><\/jats:styled-content>. Essential oils and\/or their derivatives may be one of the potential sources of antischistosomal drugs.<\/jats:p>","DOI":"10.1002\/ptr.6643","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T08:03:01Z","timestamp":1582012981000},"page":"1761-1769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010<scp><i>Schistosoma mansoni<\/i><\/scp> effects of essential oils and their components"],"prefix":"10.1002","volume":"34","author":[{"given":"Muhammad Torequl","family":"Islam","sequence":"first","affiliation":[{"name":"Department for Management of Science and Technology Development Ton Duc Thang University  Ho Chi Minh City Vietnam"},{"name":"Faculty of Pharmacy Ton Duc Thang University  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Pharmacy University of Concepcion  Concepcion Chile"},{"name":"Universidad de Concepci\u00f3n Unidad de Desarrollo Tecnol\u00f3gico (UDT)  Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-9797","authenticated-orcid":false,"given":"Bahare","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Bam University of Medical Sciences  Bam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-0528","authenticated-orcid":false,"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville AL 35899 USA"},{"name":"Aromatic Plant Research Center  230 N 1200 E, Suite 100, Lehi UT 84043 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi\u2010Rad","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2018.11.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573409913666170119114859"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2016.05.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760180489"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5749"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1994.1032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600065"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100167"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.202.63"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.06.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-6188-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16010762"},{"issue":"9","key":"e_1_2_7_16_1","first-page":"1627","article-title":"Antischistosomal and cytotoxic effects of the essential oil of Tetradenia riparia (Lamiaceae)","volume":"10","author":"Melo N. I.","year":"2015","journal-title":"Natural Product Communications"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3172-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.058"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.06.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2017\/e340"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003604"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.02.027"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.02.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.07.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2016.54.4.477"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-016-5177-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00275-19"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006590"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.05.002"},{"key":"e_1_2_7_30_1","volume-title":"Drug Plants III","author":"Haridas D.","year":"2010"},{"issue":"1","key":"e_1_2_7_31_1","first-page":"306","article-title":"Nano\u2010technology in aspects of phenolic drugs","volume":"2","author":"Islam M. T.","year":"2017","journal-title":"British Journal of Pharmaceutical and Medical Research"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5652"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061431"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651993000200011"},{"issue":"110","key":"e_1_2_7_35_1","article-title":"Applications of monoterpenic essential oils in neglected diseases: nerol in a prospection","volume":"9","author":"Ladeira Co\u00ealho M.","year":"2016","journal-title":"International Archives of Medicine"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-017-0324-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3649-z"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1997.d01-242.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6587150"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.12.003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600194"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0285-2016"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946201658004"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1350732"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3487183"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821990000400002"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199997909.001.0001"},{"issue":"3","key":"e_1_2_7_48_1","first-page":"253","article-title":"Anthelmintic activity of the natural compound (+)\u2010limonene epoxide against Schistosoma mansoni","volume":"79","author":"Moraes J.","year":"2013","journal-title":"Planta Medica"},{"issue":"6","key":"e_1_2_7_49_1","first-page":"390","article-title":"Schistosoma mansoni: Cercaricidal effects of cedarwood oil and various of its components","volume":"95","author":"Naples J. M.","year":"1992","journal-title":"The Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4517971"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900292"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100336"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2007.07.002"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1327832"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003593"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2012.971.978"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.017"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959202"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101854"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071364"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761987000800066"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2018.64.8.3"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.005"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760180478"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.08.002"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700149"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201400293"},{"key":"e_1_2_7_68_1","volume-title":"Based on the 15th model list of essential medicines 2007","author":"WHO","year":"2008"},{"key":"e_1_2_7_69_1","volume-title":"Schistosomiasis fact sheet","author":"WHO","year":"2017"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:13:03Z","timestamp":1693905183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ptr.6643"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6643","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}