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The aim of this study was to evaluate the clinical and mycological effectiveness of the topical administration of an enecalin standardized extract of <jats:italic>A. pichinchensis<\/jats:italic> for treating onychomycosis in patients with type 2 diabetes mellitus (DM2). A double blind, randomized, and controlled clinical trial was carried out that included patients with DM2 and who had mild or moderate onychomycosis. Participants were administered topically, for 6 months, a lacquer containing the encecalin standardized extract of <jats:italic>A. pichinchensis<\/jats:italic> (experimental group) or 8% ciclopirox (control group). In a large percentage of both, the control group (77.2%) and the experimental group (78.5%), clinical efficacy was detected as a decrease in the number of affected nails and a reduction in the severity of nail involvement. Without exhibiting statistically significant differences between groups, the encecalin standardized extract of <jats:italic>A. pichinchensis<\/jats:italic> was clinically and mycologically effective in the treatment of mild and moderate onychomycosis in patients with DM2. The treatment of onychomycosis in patients with DM2 implies a greater challenge, while control of blood glucose levels in these patients, played a very important role in the response of patients to treatment.<\/jats:p>","DOI":"10.1002\/ptr.6644","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T11:33:43Z","timestamp":1582371223000},"page":"1678-1686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of an encecalin standardized extract of <i>Ageratina pichinchensis<\/i> on the treatment of onychomycosis in patients with diabetes mellitus"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2239-0834","authenticated-orcid":false,"given":"Ofelia","family":"Romero\u2010Cerecero","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social (CIBIS\u2010IMSS)  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura","family":"Islas\u2010Gardu\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social (CIBIS\u2010IMSS)  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social (CIBIS\u2010IMSS)  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-7645","authenticated-orcid":false,"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social (CIBIS\u2010IMSS)  Xochitepec Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410902843301"},{"volume-title":"Cat\u00e1logo de plantas medicinales, Jard\u00edn Etnobot\u00e1nico del INAH. 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