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In this article, a dextran\u2010induced microcirculation dysfunction (MCDF) model rats were adopted to evaluate the effects and mechanism of <jats:italic>Salvia miltiorrhiza<\/jats:italic> stem\u2010leaf extracts based on plasma and urine metabonomics. The results showed the effective components of <jats:italic>S. miltiorrhiza<\/jats:italic> stem\u2010leaf could significantly improve the hemorheology and coagulation index of MCDF rats and callback the expression of endothelin\u20101 (ET\u20101), induciblenitric oxide synthase (iNOS), vascularendothelial growth factor (VEGF), P\u2010Selectin, thromboxane A2, 6\u2010keto\u2010PGF<jats:sub>1<jats:italic>\u03b1<\/jats:italic><\/jats:sub>, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and interleukin\u20101<jats:italic>\u03b2<\/jats:italic> to control group in MCDF rats. The decrease of microvessel density (MVD) in lung and thymus caused by MCDF was upgraded by <jats:italic>Salvia miltiorrhiza<\/jats:italic> stem\u2010leaf. Based on the plasma and urine metabolic data, 20 potential biomarkers were identified. These biomarkers are mainly related to linoleic acid metabolism, glutathione metabolism, pantothenate and coenzyme A biosynthesis, pentose and glucuronate interconversions, pyruvate metabolism, glyoxylate and dicarboxylate metabolism, beta\u2010alanine metabolism, and citrate cycle. The results indicated that the effective components of <jats:italic>S. miltiorrhiza<\/jats:italic> stem\u2010leaf can improve the hemorheological disorder and vascular endothelial function. Meanwhile, the effective components can regulate potential biomarkers and correlated metabolic pathway, which can provide guidance for the research and development of new drugs for MCDF.<\/jats:p>","DOI":"10.1002\/ptr.6652","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T01:09:45Z","timestamp":1584493785000},"page":"1704-1720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>Salvia miltiorrhiza<\/i> stem\u2010leaf active components of salvianolic acids and flavonoids improved the hemorheological disorder and vascular endothelial function on microcirculation dysfunction rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Chengjing","family":"Sun","sequence":"first","affiliation":[{"name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources 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