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Pers. is a well\u2010known plant in Ayurveda and named \u201c<jats:italic>Sarwa wranvishapaka<\/jats:italic>\u201d for its property to heal wounds. Traditionally, it is practiced for impotency, asthma, dyspepsia, hemorrhoids, syphilis gonorrhea, rheumatism, enlargement of kidney and spleen. It is an important component of herbal preparations like Tephroli and Yakrifti used to cure liver disorders. Various phytocompounds including pongamol, purpurin, purpurenone, tephrosin, bulnesol, tephrostachin, \u03b2\u2010sitosterol, and so on have been reported. Modern pharmacological studies have shown that the plant have wound healing, antileishmanial, anticarcinogenic, antimicrobial, antioxidant, hepatoprotective, antifertility, antispermatogenic, anti\u2010diarrheal, diuretic, and insecticidal properties. Acetylcholinesterase inhibitory action reported from this plant aids its utilization for the development of drugs for Alzheimer's and dementia neurological disorders. Among the known active compounds of <jats:styled-content style=\"fixed-case\"><jats:italic>T. purpurea<\/jats:italic><\/jats:styled-content>, tephrostachin is responsible for antiplasmodial activity, tephrosin, pongaglabol, and semiglabrin exerts antiulcer activity while quercetin, rutin, \u03b2\u2010sitosterol, and lupeol are mainly responsible for its anti\u2010inflammatory and anti\u2010cancer properties. From different toxicological studies, concentrations up to 2,000\u2009mg\/kg were considered safe. The present review comprehensively summarizes the ethnomedicine, phytochemistry, pharmacology, and toxicology of <jats:styled-content style=\"fixed-case\"><jats:italic>T. purpurea<\/jats:italic><\/jats:styled-content>. Further research on elucidation of the structure\u2013function relationship among active compounds, understanding of multi\u2010target network pharmacology and clinical applications will intensify its therapeutic potential.<\/jats:p>","DOI":"10.1002\/ptr.6657","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T05:29:16Z","timestamp":1583731756000},"page":"1902-1925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A comprehensive review on ethnomedicine, phytochemistry, pharmacology, and toxicity of <scp><i>Tephrosia purpurea<\/i><\/scp> (L.) Pers."],"prefix":"10.1002","volume":"34","author":[{"given":"A. S.","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Botany Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-1253","authenticated-orcid":false,"given":"S. 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