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The present study was designed to investigate whether the compound could reverse depressive\u2010like symptoms and investigate its possible mechanisms. Chronic Unpredictable Mild Stress (CUMS) mice were treated with fluoxetine and SG. The immobility time in forced swimming test (FST) and tail suspension test (TST) were recorded. The levels of pro\u2010inflammatory cytokines and neurotransmitters in the hippocampus were evaluated. Furthermore, the protein expressions of PI3K, AKT, mTOR, p70S6K, BDNF, and Trkb in hippocampus were detected. Rapamycin, the selective mTOR inhibitor, was used to estimate the potential mechanism. As a result, after 7\u2009days of SG treatment, the immobility time in FST and TST was declined obviously. The levels of IL\u20106, IL\u20101\u03b2, and TNF\u2010\u03b1 in the hippocampus were significantly reduced, and the quantity of 5\u2010HT and NE was raised considerably in SG\u2010treated group compared with the CUMS\u2010exposed group. Additionally, SG could up\u2010regulate the expressions of PI3K, AKT, mTOR, 70S6K, BDNF, and Trkb. The blockade of mammalian target of rapamycin signaling blunted the antidepressant effect and reversed the up\u2010regulation of BDNF expression caused by SG. These findings suggested that SG treatment alleviated depressive\u2010like symptoms via mTOR\u2010mediated BDNF\/Trkb signaling.<\/jats:p>","DOI":"10.1002\/ptr.6675","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T03:24:05Z","timestamp":1585970645000},"page":"2246-2257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Involvement of mTOR\u2010related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice"],"prefix":"10.1002","volume":"34","author":[{"given":"Hanqing","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy Ningxia Medical University  Yinchuan China"},{"name":"Ningxia Research Center of Modern Hui Medicine Engineering and Technology Ningxia Medical University  Yinchuan China"},{"name":"Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education Ningxia Medical University  Yinchuan 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