{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:26:30Z","timestamp":1769243190223,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and the Food Industry"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of <jats:styled-content style=\"fixed-case\"><jats:italic>Palmaria palmata<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>P. palmata<\/jats:italic><\/jats:styled-content>), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an 8\u2010week, randomized, double\u2010blind, placebo\u2010controlled, and parallel\u2010group comparison trial. The study enrolled Japanese participants with a serum low\u2010density protein cholesterol (LDL\u2010C) \u2265120\u2009mg\/dL. The participants were randomly assigned to take either capsules containing <jats:styled-content style=\"fixed-case\"><jats:italic>P. palmata<\/jats:italic><\/jats:styled-content> (2 g\/day) or placebo capsules. The primary endpoint was the change in LDL\u2010C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 104 participants completed the study protocol. There were no significant differences in change in LDL\u2010C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the <jats:styled-content style=\"fixed-case\"><jats:italic>P. palmata<\/jats:italic><\/jats:styled-content> group (\u22129.0 [\u221225.0, +5.0]) vs. those in the placebo group (\u22121.0 [\u221211.0, +19.0]; <jats:italic>p<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study did not show that <jats:styled-content style=\"fixed-case\"><jats:italic>P. palmata<\/jats:italic><\/jats:styled-content> had significant effect on serum LDL\u2010C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of <jats:styled-content style=\"fixed-case\"><jats:italic>P. palmata<\/jats:italic><\/jats:styled-content> in women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ptr.6680","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T15:10:28Z","timestamp":1585926628000},"page":"2303-2312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of <scp><i>Palmaria palmata<\/i><\/scp> on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double\u2010blind placebo\u2010controlled trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-2395","authenticated-orcid":false,"given":"Takahiro","family":"Takase","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"},{"name":"Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minori","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhito","family":"Toyomaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kusumi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikako","family":"Kino","sequence":"additional","affiliation":[{"name":"Regional Collaboration Department, Institute for the Promotion of Business\u2010Regional Collaboration, Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Hokkaido Industrial Technology Center  Hakodate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Kiso","sequence":"additional","affiliation":[{"name":"Regional Collaboration Department, Institute for the Promotion of Business\u2010Regional Collaboration, Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"429","article-title":"Octadecapentaenoic acid and macrophytes","volume":"9","author":"Ackman R. G.","year":"1979","journal-title":"Proceedings of the International Seaweed Symposium"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1011-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.04.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.06.029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(99)00014-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/943162"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2008.2.2.62"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.GL2017"},{"key":"e_1_2_10_12_1","first-page":"146","volume-title":"Vaimodeistvie Vodoi Zhivym Veshchestvom Tr. Mezhdunar","author":"Kravtsova Y.","year":"1979"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"1072","article-title":"Enteromorpha flexuosa improves insulin sensitivity and metabolic control in fructose\u2010induced diabetic rats","volume":"3","author":"Mahmoud A.","year":"2015","journal-title":"Journal of Endocrinology, Diabetes & Obesity"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.37"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.1212"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-10-200311180-00007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E-125"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0379"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5235"},{"key":"e_1_2_10_20_1","unstructured":"Rhatigan P.(2009). Irish Seaweed Kitchen. The comprehensive guide to healthy everyday cooking with seaweeds 288: Booklink."},{"issue":"1","key":"e_1_2_10_21_1","article-title":"Dietary fibre and cardiovascular health","volume":"27","author":"S\u00e1nchez\u2010Muniz F. J.","year":"2012","journal-title":"Nutricion Hospitalaria"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.8193"},{"key":"e_1_2_10_23_1","unstructured":"Takeda Pharmaceutical Company. (2018). LOTRIGA (Omega\u20103\u2010Acid ethyl esters) Application for marketing approval; new drug application (NDA). Retrieved fromhttp:\/\/www.pmda.go.jp\/drugs\/2012\/P201200127\/index.html(in Japanese)."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.836"},{"key":"e_1_2_10_25_1","first-page":"189","volume-title":"Dietary reference intakes for Japanese","author":"The Ministry of Health, Labour, and Welfare, Japan","year":"2005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3136\/fstr.10.147"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.42.725"},{"key":"e_1_2_10_28_1","first-page":"807","volume-title":"Microbial lipids","author":"Wood B. J.","year":"1988"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2015.06.003"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:13:17Z","timestamp":1693930397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,3]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/ptr.6680"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6680","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,3]]},"assertion":[{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}