{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:19:48Z","timestamp":1788715188552,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    <jats:italic>Bacopa monnieri<\/jats:italic>\n                    (L.) is widely used in Ayurvedic medicine as a neural tonic for improving intelligence and memory. Several studies highlighted its efficacy in neuropsychiatric diseases but there is no evidence regarding anhedonia. Aim of the present work was to preclinically and clinically test against anhedonia a standardized\n                    <jats:italic>B<\/jats:italic>\n                    .\n                    <jats:italic>monnieri<\/jats:italic>\n                    extract (20% bacosides). In a mouse model of a depressive\u2010like syndrome induced by lipopolysaccharide (LPS), the daily administration of the extract (50\u2013200\u2009mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , p.o.) for 1\u2009week, dose\u2010dependently counteracted the immobility time in Porsolt and Tail suspension tests (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). At the sucrose preference test (directly related to the ability for feeling pleasure) the extract treatment (100 and 200\u2009mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) counteracted the reduction of sucrose intake induced by LPS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Moreover,\n                    <jats:italic>B<\/jats:italic>\n                    .\n                    <jats:italic>monnieri<\/jats:italic>\n                    significantly reduced cytokines, cortisol, and artemin LPS\u2010dependent alterations in plasma while increased the brain\u2010derived neurotrophic factor levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The efficacy of the same extract was tested in a clinical study in which 42 patients with significant degree of anhedonia (evaluated as Snaith\u2010Hamilton Pleasure Scale [SHAPS] score\u2009\u2265\u20093) were enrolled. Patients were divided into two groups and treated with citalopram or citalopram associated with\n                    <jats:italic>B<\/jats:italic>\n                    .\n                    <jats:italic>monnieri<\/jats:italic>\n                    (300\u2009mg bid) for 4\u2009weeks. The Pears Sample\n                    <jats:italic>T<\/jats:italic>\n                    \u2010test showed a significant improvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) in relevant scales (Hamilton depression rating scale, SHAPS, and strength and difficulties questionnaire) in the extract\u2010treated group in comparison to citalopram alone was recorded. These data suggest that\n                    <jats:italic>B<\/jats:italic>\n                    .\n                    <jats:italic>monnieri<\/jats:italic>\n                    extract may be effective for the management of anhedonia and therefore should be considered for future controlled trials.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6684","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T03:44:55Z","timestamp":1585712695000},"page":"2331-2340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["<i>Bacopa monnieri<\/i>\n                    as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation"],"prefix":"10.1002","volume":"34","author":[{"given":"Laura","family":"Micheli","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health\u2014NEUROFARBA\u2014Pharmacology and Toxicology Section University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Spitoni","sequence":"additional","affiliation":[{"name":"Department Neurofarba, Psychiatry Section University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4432","authenticated-orcid":false,"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health\u2014NEUROFARBA\u2014Pharmacology and Toxicology Section University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Bilia","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cUgo Schiff\u201d University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health\u2014NEUROFARBA\u2014Pharmacology and Toxicology Section University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pallanti","sequence":"additional","affiliation":[{"name":"Department Neurofarba, Psychiatry Section University of Florence  Florence Italy"},{"name":"Department of Psychiatry and Behavioral Sciences Albert Einstein College of Medicine  New York New York USA"},{"name":"Institute of Neuroscience  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.05.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2014.11.3.297"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9085273"},{"key":"e_1_2_8_6_1","first-page":"271359","article-title":"Systemic immune activation leads to neuroinflammation and sickness behavior in mice","volume":"2013","author":"Biesman S.","year":"2013","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.01.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(02)00008-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22490"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7916(00)00012-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2326-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320706"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-140.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.02085.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200501000-00003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300506"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2017.14.1.74"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-15"},{"key":"e_1_2_8_22_1","first-page":"1","volume-title":"Q2 (A)Validation of analytical procedures: Text and methodology","author":"ICH, International Conference on Harmonisation","year":"2005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14020138"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-100"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.02.018"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2029-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0011-z"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0610"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12955"},{"key":"e_1_2_8_30_1","article-title":"Clinical evaluation of memory enhancing properties of memory plus in children with attention deficit hyperactivity disorder","volume":"42","author":"Negi K. S.","year":"2000","journal-title":"Indian Journal of Psychiatry"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.07.073"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002148"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0756-2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200403000-00006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.147181"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.06.001"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000575"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00288"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/266730a0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.829"},{"key":"e_1_2_8_41_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric (interview (M.I.N.I): The development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.025"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.013"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.167.1.99"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2010.7.4.236"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.06.006"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102758"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:13:20Z","timestamp":1693916000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/ptr.6684"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6684","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2019-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}