{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:12:13Z","timestamp":1766067133241,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017\u2010R1D1A3B03036020"],"award-info":[{"award-number":["NRF\u20102017\u2010R1D1A3B03036020"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Gastroesophageal reflux disease (GERD) is a disease that stomach contents continually refluxing into esophagus causes symptoms and\/or complications. The study was working to find natural plant extracts with good effects and small side effects to treat reflux esophagitis (RE). The anti\u2010inflammatory effects of hexane extract of <jats:italic>Magnolia sieboldii<\/jats:italic> (MsHE) were conducted on lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 macrophage cells. The ameliorative effects of MsHE on esophageal damage in rats induced by gastric acid reflux was explored in vivo. The results showed that MsHE decreased the production of nitric oxide (NO) and expression levels of iNOS, COX\u20102 and TNF\u2010\u03b1 on LPS\u2010stimulated RAW 264.7 cells and MsHE treatment ameliorated the rats' esophageal tissue damage induced by gastric acid and inhibited the increase of inflammatory mediators and pro\u2010inflammatory cytokines by regulating NF\u2010\u03baB signaling pathway. In addition, MsHE protected the function of barrier of epithelial cells against inflammatory conditions through increasing the expression of tight junctions. Furthermore, liquid chromatography\u2010mass spectrometry analysis was used for determine the active ingredients contained in MsHE. The results show that MsHE can alleviate experimental rat RE by regulating NF\u2010\u03baB signaling pathway. In summary, MsHE may be used as a source material of drug candidate for the treatment of RE.<\/jats:p>","DOI":"10.1002\/ptr.6689","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T10:16:57Z","timestamp":1586254617000},"page":"2385-2396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ameliorative effects of <scp><i>Magnolia sieboldii<\/i><\/scp> buds hexane extract on experimental reflux esophagitis"],"prefix":"10.1002","volume":"34","author":[{"given":"Li","family":"Nan","sequence":"first","affiliation":[{"name":"Department of Crop Science and Biotechnology Chonbuk National University  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Hwa","family":"Nam","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine  Naju\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-2258","authenticated-orcid":false,"given":"Byung Yong","family":"Park","sequence":"additional","affiliation":[{"name":"College of Medicine and Biosafety Research Institute Chonbuk National University  Iksan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Center of Bioactive Materials Chonbuk National University  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-4399","authenticated-orcid":false,"given":"Byung Kil","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Crop Science and Biotechnology Chonbuk National University  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.09.034"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.10.042"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"Alvarez\u2010Suarez J.M. 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