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This meta\u2010analysis was performed to evaluate the effect of fenugreek supplementation on human serum lipid profile. Data sources were PubMed, EMBASE, Scopus, and Coherence library which were searched systematically from January 2000 up to December 2019. Inclusion criteria were randomized clinical trial (RCT) study design, at least one of lipid profile components (triglyceride [TG], total cholesterol [TC], low\u2010density lipoprotein cholesterol, and high\u2010density lipoprotein cholesterol) levels measured before fenugreek use and one of the lipid components level reported as result. The pooled weighted mean difference (MD) and its 95% confidence interval (CI) were calculated and pooled using a random\u2010effect model. Only articles published in English were considered. Fifteen RCTs involving 281 cases consumed fenugreek and 255 control cases in controlled group (11 articles) and 136 cases in uncontrolled group (4 articles) were analyzed in our study. Pooled data of indicated a significant impact of fenugreek supplementation on lowering TC (\u22121.13 [\u22121.88, \u22120.37]; <jats:italic>p<\/jats:italic> =\u2009.003), low\u2010density lipoprotein (LDL) (\u22121.26 [\u22122.09, \u22120.43]; <jats:italic>p<\/jats:italic> =\u2009.003), and TG (\u22121.07 [\u22121.82, \u22120.33]; <jats:italic>p<\/jats:italic> =\u20090.005) and increasing the high\u2010density lipoprotein (HDL) level (0.70 [0.07, 1.34]; <jats:italic>p<\/jats:italic> =\u2009.03) compared with the control group. There were no significant differences in TC, TG, and LDL between pre\u2010 and post\u2010fenugreek studies in the noncontrolled studies however, the result of combination of four studies without control group showed a significant increase in mean HDL (0.81 [0.33,1.29]; <jats:italic>p<\/jats:italic>\u2010value = .001). The results of subgroup analysis showed that the fenugreek reduced the TG and LDL and increases HDL levels in diabetic subjects more effectively. Fenugreek supplementation significantly improved lipid profile (LDL, TG, TC, and HDL). It could be considered as an effective lipid\u2010lowering medicinal plant. Further high\u2010quality studies are needed to firmly establish the clinical efficacy of the plant.<\/jats:p>","DOI":"10.1002\/ptr.6690","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:40:03Z","timestamp":1589002803000},"page":"2230-2245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Effect of fenugreek consumption on serum lipid profile: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-7128","authenticated-orcid":false,"given":"Kiyan","family":"Heshmat\u2010Ghahdarijani","sequence":"first","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Mashayekhiasl","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-3839","authenticated-orcid":false,"given":"Atefeh","family":"Amerizadeh","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute sfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Teimouri Jervekani","sequence":"additional","affiliation":[{"name":"Hypentension Research Center, Cardiovascular Research Institute  Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-5558","authenticated-orcid":false,"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.26719\/2000.6.1.83"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/1096620041224201"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_10_5_1","first-page":"e56","article-title":"Heart disease and stroke statistics","volume":"139","author":"Benjamin E. 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