{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:53:19Z","timestamp":1784307199454,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873175"],"award-info":[{"award-number":["51873175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["17JR5RA332"],"award-info":[{"award-number":["17JR5RA332"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>High altitude cerebral edema (HACE) is a high altitude malady caused by acute hypobaric hypoxia (AHH), in which pathogenesis is associated with oxidative stress and inflammatory cytokines. <jats:italic>Potentilla anserina<\/jats:italic> L is mainly distributed in Tibetan Plateau, and its polysaccharide possesses many physiological and pharmacological properties. In the present study, the protective effect and potential treatment mechanism of <jats:italic>Potentilla anserina<\/jats:italic> L polysaccharide (PAP) in HACE were explored. First, we measured the brain water content and observed the pathological changes in brain tissues, furthermore, malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and glutathione (GSH) were evaluated by kits. Finally, the protein contents and mRNA expressions of pro\u2010inflammatory (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, vascular endothelial cell growth factor [VEGF], NF\u2010\u03baB, and hypoxia inducible factor\u20101 \u03b1 [HIF\u20101\u03b1]) were detected by ELISA kits, RT\u2010PCR, and western blotting. The results demonstrated that PAP reduced the brain water content, alleviated brain tissue injury, reduce the levels of MDA and NO, and increased the activity of SOD and GSH level. In addition, PAP blocking the NF\u2010\u03baB and HIF\u20101\u03b1 signaling pathway activation inhibited the generation of downstream pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, and VEGF). Therefore, PAP has a potential to treat and prevent of HACE by suppression of oxidative stress and inflammatory response.<\/jats:p>","DOI":"10.1002\/ptr.6691","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T12:55:28Z","timestamp":1587041728000},"page":"2397-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Polysaccharide extracted from <scp><i>Potentilla anserina<\/i><\/scp> L ameliorate acute hypobaric hypoxia\u2010induced brain impairment in rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Jipeng","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Biochemistry College of Life Science, Northwest Normal University  Lanzhou China"},{"name":"Department of Biochemistry Bioactive Products Engineering Research Center for Gansu Distinctive Plants  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Gansu University of Chinese Medicine  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Life Science, Northwest Normal University  Lanzhou China"},{"name":"Department of Biochemistry Bioactive Products Engineering Research Center for Gansu Distinctive Plants  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Gansu University of Chinese Medicine  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-9308","authenticated-orcid":false,"given":"Maoxing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Prevention and Treatment for Injury in Plateau of PLA, Department of Pharmacy The 940th Hospital of Joint Logistic Support Force of Chinese PLA  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Gansu University of Chinese Medicine  Lanzhou China"},{"name":"Department of Pharmacy College of Pharmacy, Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169534"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00704.2003"},{"key":"e_1_2_7_4_1","first-page":"64","article-title":"High altitude and free radicals","volume":"3","author":"Bakonyi T.","year":"2004","journal-title":"Journal of Sports Science & Medicine"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01664.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00106.2012"},{"key":"e_1_2_7_7_1","first-page":"311","article-title":"Review on Potentilla anserina L. a kind of Tibetan herbs","volume":"25","author":"Chen H. Q.","year":"2000","journal-title":"Journal of Clinical Materials Science: Materials in Medicine"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2017.01.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2007.8404"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.03.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.06.004"},{"key":"e_1_2_7_12_1","first-page":"209","article-title":"The changes of inducible nitric oxide synthase activity and apoptosis\u2010related gene expression in endotoxemia\u2010induced rat diaphragm","volume":"29","author":"Fang Y. Y.","year":"2013","journal-title":"Chinese Journal of Applied Physiology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.02.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.08.083"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2009.08.018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.02.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.07.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00362.2013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149309"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666160920123911"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6443"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.02.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32834873fd"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.07.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.06.010"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.08.026"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1170com"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147949"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0528-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.157669"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00154-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2007.1015"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2009.06.011"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910283"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.09.010"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2009.10.073"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60028-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.04.059"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.01.005"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2018.02.004"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.01.037"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.6691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.6691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.6691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:12:51Z","timestamp":1693930371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.6691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/ptr.6691"],"URL":"https:\/\/doi.org\/10.1002\/ptr.6691","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]},"assertion":[{"value":"2019-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}