{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T01:55:27Z","timestamp":1781488527376,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860773"],"award-info":[{"award-number":["81860773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of the study was to investigate the effect of liquiritin on neuroendocrine\u2010immune network in menopausal rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liquiritin groups were respectively given liquiritin suspension at the dose of 80, 40, and 20\u2009mg\/kg, once a day for continuous 30\u2009days after the removal of bilateral ovaries to induce the menopausal rat model. Behavioral experiments were conducted and the organs were weighed for the viscera index. The content of estradiol (E<jats:sub>2<\/jats:sub>) and follicle\u2010stimulating hormone (FSH) in the serum and 5\u2010hydroxytryptamine (5\u2010HT) and norepinephrine (NE) in hypothalamus were assayed by enzyme linked immunosorbent assay kits. Morphological changes of uterus and adrenal gland were observed by hematoxylin\u2013eosin (HE) staining and estrogen receptor (ER) expression of uterus and spleen were determined by immunohistochemical staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the nervous system, liquiritin relieved menopausal depression and up\u2010regulated the levels of 5\u2010HT and NE in hypothalamus; for the endocrine system, it raised the concentrations of E<jats:sub>2<\/jats:sub> and FSH in serum, relieved the histological changes of uterus and adrenal gland and increased the expression of ER in uterus; for the immune system, it increased the thymus index and the expression of ER in spleen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liquiritin improved menopausal syndrome in multiple ways by affecting the neuro\u2010endocrine\u2010immune network.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ptr.6696","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:35:35Z","timestamp":1586759735000},"page":"2665-2674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of liquiritin on neuroendocrine\u2010immune network in menopausal rat model"],"prefix":"10.1002","volume":"34","author":[{"given":"Xin\u2010Yi","family":"Lan","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Experimental Center of Food Science Research, Shandong Drug and Food Vocational College  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-0562","authenticated-orcid":false,"given":"Chun\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"},{"name":"Tang Center of Herbal Medicine Research and Department of Anesthesia and Critical Care University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-5183","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"},{"name":"School of Pharmacy Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Tang Center of Herbal Medicine Research and Department of Anesthesia and Critical Care University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Su","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tang Center of Herbal Medicine Research and Department of Anesthesia and Critical Care University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.196022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4000"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798764861"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010843"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"299","article-title":"Effects of menopause on autoimmune diseases","volume":"7","author":"Farage M. 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