{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:08:36Z","timestamp":1790482116151,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    Pharmacological studies were performed in mice on the methanol extract of\n                    <jats:italic>Tinospora crispa<\/jats:italic>\n                    (TC), and of its hexane (HF) and chloroform (CF) fractions. Significant antinociceptive activity was observed for TC, HF, and CF in the acetic acid\u2010induced writhing and formalin\u2010induced paw licking tests. Anxiolytic and antidepressant activities were assessed using the open field, hole board, and elevated plus maze (EPM) tests. TC, HF, and CF demonstrated a significant decrease in spontaneous locomotor activity. They also showed an increase in the number of head\u2010dippings in the hole\u2010board test, suggesting decreased fearfulness. TC, and most of its fractions, showed a significant increase of the time spent in the opened arm of the EPM, indicating reduced anxiety. This study provides some support to explain the traditional use of\n                    <jats:italic>T. crispa<\/jats:italic>\n                    as a remedy for pain.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6725","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:54:44Z","timestamp":1589932484000},"page":"2978-2984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of\n                    <i>Tinospora crispa<\/i>"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3335-0368","authenticated-orcid":false,"given":"Ahmed","family":"Rakib","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahriar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ashiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Muhammad Nasir","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Science University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkajyoti","family":"Paul","sequence":"additional","affiliation":[{"name":"Drug Discovery GUSTO A Research Group  Chittagong Bangladesh"},{"name":"Department of Microbiology Jagannath University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nazim Uddin","family":"Chy","sequence":"additional","affiliation":[{"name":"Drug Discovery GUSTO A Research Group  Chittagong Bangladesh"},{"name":"Pharmacognosy and Phytochemistry Laboratories, Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2272","authenticated-orcid":false,"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[{"name":"Drug Discovery GUSTO A Research Group  Chittagong Bangladesh"},{"name":"Department of Pharmacy BGC Trust University Bangladesh  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-5261","authenticated-orcid":false,"given":"Veronique","family":"Seidel","sequence":"additional","affiliation":[{"name":"Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","first-page":"59","article-title":"Tinospora crispa (L.) 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