{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:36:49Z","timestamp":1792017409126,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    <jats:italic>Nigella sativa<\/jats:italic>\n                    L. (black seed) is one of the main medicinal plants frequently cited in traditional Persian medicine manuscripts for management of acne vulgaris. The present study was designed to investigate the efficacy of a topical preparation from\n                    <jats:italic>N. sativa<\/jats:italic>\n                    in acne vulgaris. In a randomized double\u2010blind controlled clinical trial, 60 patients (30 patients in treatment and 30 in placebo group) were randomly received\n                    <jats:italic>N. sativa<\/jats:italic>\n                    hydrogel (standardized based on thymoquinone) or placebo hydrogel, twice daily for 60\u2009days. The Investigator's Global Assessment (IGA) grading score was recorded for each patient. Moreover, acne disability index (ADI) was evaluated using a standard questionnaire filled out by the patients at the beginning and end of the study. A 78% mean reduction in the IGA score on the\n                    <jats:italic>N. sativa<\/jats:italic>\n                    \u2010treated group was recorded compared with 3.3% on the vehicle\u2010treated one. Significant reductions in the number of comedones, papules, and pustules were observed in the treatment group compared with placebo after 2\u2009months. Also, ADI was decreased 63.49% in the treatment versus 4.5% in the placebo groups. No adverse event was recorded.\n                    <jats:italic>N. sativa<\/jats:italic>\n                    hydrogel had significant effects on improving the symptoms of acne vulgaris with acceptable tolerability.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6739","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T04:00:42Z","timestamp":1592366442000},"page":"3052-3062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The effect of a hydrogel made by\n                    <i>Nigella sativa<\/i>\n                    L. on acne vulgaris: A randomized double\u2010blind clinical trial"],"prefix":"10.1002","volume":"34","author":[{"given":"Samaneh","family":"Soleymani","sequence":"first","affiliation":[{"name":"Department of Traditional Pharmacy, School of Persian Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Zargaran","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy, School of Persian Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-6521","authenticated-orcid":false,"given":"Mohammad Hosein","family":"Farzaei","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Iranpanah","sequence":"additional","affiliation":[{"name":"Student's Research Committee, Faculty of Pharmacy Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Heydarpour","sequence":"additional","affiliation":[{"name":"Social Development &amp; Health Promotion Research Center Health Institute, Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-4350","authenticated-orcid":false,"given":"Roja","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy, School of Persian Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"140","article-title":"Treatment of acne vulgaris with Nigella sativa oil lotion","volume":"2","author":"Abdul\u2010Ameer N.","year":"2010","journal-title":"Iraqi Postgraduate Medical Journal"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-012-9899-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdds.2015.04.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923970903307552"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1474-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-005-0143-7"},{"issue":"6","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4103\/0253-7613.89815","article-title":"Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial","volume":"43","author":"Choudhury S.","year":"2011","journal-title":"Indian Journal of Pharmacology"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.103650"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"208","article-title":"Role of Nigella sativa in ameliorating chloramphenicol induced tissue damage in rats","volume":"5","author":"Ebaid H.","year":"2011","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00139-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1658-3612(06)70003-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530630-000000000-00000"},{"issue":"12","key":"e_1_2_8_16_1","first-page":"929","article-title":"Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial effects","volume":"17","author":"Forouzanfar F.","year":"2014","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.4515"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"2958","article-title":"Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study","volume":"6","author":"Ghovvati M.","year":"2019","journal-title":"Journal of Biomedical Research"},{"key":"e_1_2_8_19_1","volume-title":"Clinical dermatology E\u2010book: A color guide to diagnosis and Therapy","author":"Habif T. 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