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Evidences suggested in different studies that traditionally used plants in Asia, China, and Europe significantly affect aging and AD involved neurodegeneration pathways. Research into ethnobotanicals for impaired memory and cognition has been burgeoned in last decades. The inclusion and exclusion criteria for the plant selection were based on reputed herbs recommended for treatment of neurological disorders and their scientific validation to cure neurodegenerative disorders. A range of traditional plants imparts effects via acetylcholinesterase activity, \u03b2\u2010amyloid peptide formation in plaques, neurotrophic factors and through antioxidant activity. On one side preclinical investigations identified promising drug candidates for AD, on the other side, clinical evidences are still pending. Presently, according to WHO, around more than 80% world population relay on natural remedies to cure their health related issues. Plants contain rich source of primary and secondary metabolites for improving health problems. Pharmaceutical industry is facing intriguing challenges like elevated cost and unendurable risk management due to the high burden of neurodegenerative disorders. A significant shift of drug discovery is being witnessed from synthetic moieties to herbal formulation.<\/jats:p>","DOI":"10.1002\/ptr.6742","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T15:09:50Z","timestamp":1591024190000},"page":"3089-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders"],"prefix":"10.1002","volume":"34","author":[{"given":"Muqeet","family":"Wahid","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Bahauddin Zakariya University  Multan Pakistan"},{"name":"Institute of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Ali","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Saqib","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambreen","family":"Aleem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumbal","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy COMSATS University Islamabad  Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Afzal","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy COMSATS University Islamabad  Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Biotechnology COMSATS University Islamabad  Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujaat Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy COMSATS University Islamabad  Abbottabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-9416","authenticated-orcid":false,"given":"Muhammad Hassham Hassan","family":"Bin Asad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy COMSATS University Islamabad  Abbottabad Pakistan"},{"name":"Department of Genetics, Institute of Fundamental Medicine and Biology Kazan Federal University  Kazan Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.11.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.56072"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2013.1431"},{"issue":"12","key":"e_1_2_7_6_1","first-page":"CR555","article-title":"The effect of Nigella sativa L. 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