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The effects of alpha\u2010mangostin, the main component of mangosteen, on the neuropathic pain caused by chronic constriction injury (CCI) were evaluated in rats. In treatment groups, alpha\u2010mangostin (10, 50, 100\u2009mg\/kg\/day, i.p.) was administered from Day 0, the day of surgery, for 14\u2009days. The degree of heat hyperalgesia, cold, and mechanical allodynia was assessed on Days 0, 3, 5, 7, 10, and 14. The lumbar spinal cord levels of MDA, GSH, inflammatory markers (TLR\u20104, TNF\u2010\u03b1, MMP2, COX2, IL\u20101\u03b2, iNOS, and NO), apoptotic markers (Bcl\u20102, Bax, and caspase\u20103) were measured by western blot on Days 7 and 14. Rats in the CCI group showed thermal hyperalgesia, cold, and mechanical allodynia on Days 3\u201314. All concentrations of alpha\u2010mangostin alleviated CCI\u2010induced behavioral alterations. MDA level augmented and GSH level decreased in the CCI group and alpha\u2010mangostin (50, 100\u2009mg\/kg) reversed the alterations. An enhancement in the levels of all inflammatory markers, Bax, and caspase\u20103 was shown on Days 7 and 14, which was controlled by alpha\u2010mangostin (50\u2009mg\/kg). The detected antinociceptive effects of alpha\u2010mangostin may be mediated through antioxidant, anti\u2010inflammatory, and antiapoptotic properties.<\/jats:p>","DOI":"10.1002\/ptr.6768","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T13:41:12Z","timestamp":1593265272000},"page":"3211-3225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Investigating the ameliorative effect of alpha\u2010mangostin on development and existing pain in a rat model of neuropathic pain"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-572X","authenticated-orcid":false,"given":"Mahboobeh","family":"Ghasemzadeh Rahbardar","sequence":"first","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad 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