{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:54Z","timestamp":1777870854935,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>A group of patients with pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) were reported from China in December 2019. Although several antiviral drugs are widely tested, none of them has been approved as specific antiviral therapy for coronavirus disease 2019 (COVID\u201019). Accumulating evidence established a hyperinflammatory states or cytokine storm in COVID\u201019. Among these cytokines, IL\u20106 plays a key role in cytokine storm and can predict the adverse clinical outcomes and fatality in these patients. Based on the evidence of the significant role of IL\u20106 in cytokine storm, diabetes mellitus, and cardiovascular diseases as principal comorbidities, it seems that anti\u2010cytokine therapy may be useful in patients with severe COVID\u201019 to reduce mortality. Recent studies demonstrated that herbal\u2010derived natural products had immunosuppressive and anti\u2010inflammatory properties and exhibited exceptional act on mediators of inflammation. Parthenolide is the principal sesquiterpene lactones and the main biologically active constituent <jats:italic>Tanacetum parthenium<\/jats:italic> (commonly known as feverfew) which has could significantly reduce IL\u20101, IL\u20102, IL\u20106, IL\u20108, and TNF\u2010\u03b1 production pathways established in several human cell line models in vitro and in vivo studies. Therefore, parthenolide may be one of the herbal candidates for clinical evaluation.<\/jats:p>","DOI":"10.1002\/ptr.6776","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T07:23:50Z","timestamp":1590823430000},"page":"2429-2430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Cytokine storm in <scp>COVID<\/scp>\u201019 and parthenolide: Preclinical evidence"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-3749","authenticated-orcid":false,"given":"Mohsen","family":"Bahrami","sequence":"first","affiliation":[{"name":"Academic Center for Education Culture and Research  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Kamalinejad","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seied Amirhossein","family":"Latifi","sequence":"additional","affiliation":[{"name":"Traditional and Complementary Medicine Research Center Arak University of Medical Sciences  Arak Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-2157","authenticated-orcid":false,"given":"Farhad","family":"Seif","sequence":"additional","affiliation":[{"name":"Department of Immunology &amp; Allergy Academic Center for Education, Culture, and Research  Tehran Iran"},{"name":"Neuroscience Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-8648","authenticated-orcid":false,"given":"Majid","family":"Dadmehr","sequence":"additional","affiliation":[{"name":"School of Persian Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"e_1_2_1_5_2_1","first-page":"111","article-title":"Herbal medicines for immunosuppression","volume":"11","author":"Amirghofran Z.","year":"2012","journal-title":"Iranian Journal of Allergy, Asthma, and Immunology"},{"key":"e_1_2_1_5_3_1","first-page":"269","article-title":"COVID\u201019: Immunopathology and its implications for therapy. 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