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Since time immemorial, the genus has popularly been used in Southern Europe, as well as on the American continent as a spice now known all over the world under the name \u201coregano\u201d or \u201cpizza\u2010spice.\u201d<jats:italic>Origanum<\/jats:italic>plants are also employed to prepare bitter tinctures, wines, vermouths, beer, and kvass. The major components of<jats:italic>Origanum<\/jats:italic>essential oil are various terpenes, phenols, phenolic acids, and flavonoids with predominant occurrence of carvacrol and thymol (with reasonable amounts of<jats:italic>p<\/jats:italic>\u2010cymen and \u2010terpinene) or of terpinene\u20104\u2010ol, linalool, and sabinene hydrate. Many species of<jats:italic>Origanum<\/jats:italic>genus are used to treat kidney, digestive, nervous, and respiratory disorders, spasms, sore throat, diabetes, lean menstruation, hypertension, cold, insomnia, toothache, headache, epilepsy, urinary tract infections, etc.<jats:italic>Origanum<\/jats:italic>essential oil showed potent bioactivities owing to its major constituents' carvacrol, thymol, and monoterpenes. Several preclinical studies evidenced its pharmacological potential as antiproliferative or anticancer, antidiabetic, antihyperlipidemic, anti\u2010obesity, renoprotective, antiinflammatory, vasoprotective, cardioprotective, antinociceptive, insecticidal, and hepatoprotective properties. Its nanotechnological applications as a promising pharmaceutical in order to enhance the solubility, physicochemical stability, and the accumulation rate of its essential oils have been investigated. However,<jats:italic>Origanum<\/jats:italic>has been reported causing angioedema, perioral dermatitis, allergic reaction, inhibition of platelet aggregation, hypoglycemia, and abortion. Conclusive evidences are still required for its clinical applications against human medical conditions. Toxicity analyses and risk assessment will aid to its safe and efficacious application. In addition, elaborate structure\u2013activity studies are needed to explore the potential use of<jats:italic>Origanum<\/jats:italic>\u2010derived phytochemicals as promising drug candidates.<\/jats:p>","DOI":"10.1002\/ptr.6785","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T06:52:49Z","timestamp":1597301569000},"page":"95-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Phytochemical constituents, biological activities, and health\u2010promoting effects of the genus<i>Origanum<\/i>"],"prefix":"10.1002","volume":"35","author":[{"given":"Mehdi","family":"Sharifi\u2010Rad","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology, Faculty of Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Berkay Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences Canakkale Onsekiz Mart University Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Antika","sequence":"additional","affiliation":[{"name":"Graduate Program of Molecular Biology and Genetics, Institute of Natural and Applied Sciences Canakkale Onsekiz Mart University Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahare","family":"Salehi","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Bam University of Medical Sciences Bam Iran"},{"name":"Student Research Committee, School of Medicine Bam University of Medical Sciences Bam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba Boyunegmez","family":"Tumer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Science Canakkale Onsekiz Mart University Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidambaram","family":"Kulandaisamy Venil","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Anna University Regional Campus\u2010Coimbatore Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitishree","family":"Das","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology &amp; 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