{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:36:29Z","timestamp":1790922989296,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nonalcoholic fatty liver disease (NAFLD) is characterized by oxidative stress and inflammation in the hepatocytes\n                      <jats:italic>.<\/jats:italic>\n                      Saffron and its constituents are reported to have several properties such as anti\u2010inflammatory and anti\u2010diabetic effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In a randomized double\u2010blind placebo\u2010controlled trial with two parallel groups including 76 eligible men and female patients with NAFLD aged 18\u201365, recruited from Hazrat Rasul Akram Hospital in Tehran, Iran. NAFLD was defined by a Gastroenterologist based on the American Gastrointestinal and Liver Association standards. Participants were randomly assigned to two groups receiving daily supplementation of either one tablet of 100\u2009mg saffron (\n                      <jats:italic>n<\/jats:italic>\n                      =\u200938) or one placebo (\n                      <jats:italic>n<\/jats:italic>\n                      =\u200938) for 12\u2009weeks. The primary outcome was high sensitive C\u2010reactive protein (hs\u2010CRP) and secondary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF\u2010\u03b1), malondialdehyde (MDA), total anti\u2010oxidant capacity (TAC), leptin, adiponectin, anthropometric, and body composition Both groups were assigned similar diet and physical activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the treatment group, significant decreases in hs\u2010CRP (\u22121.80\u2009ng\/ml, 95% CI = \u22122.97, \u22120.63,\n                      <jats:italic>p<\/jats:italic>\n                      = .032), leptin (\u22120.27\u2009ng\/ml, 95% CI = \u22120.65, \u22120.10,\n                      <jats:italic>p<\/jats:italic>\n                      = .040), MDA (\u22121.01\u2009ng\/ml, 95% CI = \u22121.89, \u22120.14,\n                      <jats:italic>p<\/jats:italic>\n                      = .023) and significant increase in TAC (0.34\u2009\u03bcmol\/L, 95% CI = 0.08, 0.61,\n                      <jats:italic>p<\/jats:italic>\n                      = .011) were observed compared to the placebo group. However, there were no significant changes in serum alanine aminotransferase, AST, TNF\u2010\u03b1, body composition, and anthropometric indexes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the present study, 12\u2009weeks of 100\u2009mg of saffron supplementation indicated beneficial effects on serum levels of some inflammatory, oxidative stress, and adipokines biomarkers but it had no significant effect on serum concentrations of liver enzymes, anthropometric, and body composition measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ptr.6791","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T03:59:13Z","timestamp":1597463953000},"page":"3367-3378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"34","author":[{"given":"Farnaz","family":"Kavianipour","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-8561","authenticated-orcid":false,"given":"Naheed","family":"Aryaeian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, 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