{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:55:26Z","timestamp":1790492126536,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Doctoral Scientific Research Foundation of Liaoning Province","award":["2019-BS-233"],"award-info":[{"award-number":["2019-BS-233"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    The present study aimed to examine the antidepressant actions of the composition fractions of\n                    <jats:italic>Schisandra chinensis<\/jats:italic>\n                    using LPS\u2010induced mice. Animals were treated with total extracts (SCE), lignans (SCL), polysaccharides (SCPS), and essential oil (SCVO), and then subjected to behavioral tests. The forced swimming test (FST) and tail suspension test (TST) were used as predictive animal models of antidepressant activity. Total extracts and lignans significantly decreased the duration of immobility in FST and TST. We found that treatment with SCE and SCL could significantly decrease the levels of pro\u2010inflammatory cytokines both in the periphery and central nervous system (CNS). This was confirmed by the histopathological examination of the colon. The RT\u2010PCR results demonstrated that SCE and SCL could greatly inhibit the TLR4\/NF\u2010\u03baB\/IKK\u03b1 signaling pathway. In addition, the concentrations of Butyric acid and Propionic acid were upregulated by the administration, and the decreased diversity of intestinal microbiota and alterations of the relative proportions of\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    and\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    phylum members,\n                    <jats:italic>Barnesiella<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    genus members in LPS\u2010induced mice were restored as well. All results suggested that lignans is the effective fraction of\n                    <jats:italic>S.chinensis<\/jats:italic>\n                    to ameliorating depressive disorders, which its anti\u2010inflammation activity possibly involved in the bidirectional connection between gut microbiota and brain.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6799","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T02:05:39Z","timestamp":1596679539000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["<i>Schisandra chinensis<\/i>\n                    ameliorates depressive\u2010like behaviors by regulating microbiota\u2010gut\u2010brain axis via its anti\u2010inflammation activity"],"prefix":"10.1002","volume":"35","author":[{"given":"Tingxu","family":"Yan","sequence":"first","affiliation":[{"name":"School of Functional Food and Wine Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizhi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Functional Food and Wine Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Functional Food and Wine Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosai","family":"He","sequence":"additional","affiliation":[{"name":"School of Functional Food and Wine Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-4350","authenticated-orcid":false,"given":"Ying","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Functional Food and Wine Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-200"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00034"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"651","article-title":"Current understanding of the neurobiology of major depressive disorder","volume":"56","author":"Chiri\u0163\u0103 A. 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