{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:49:37Z","timestamp":1781002177043,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Green tea extract (GTE) has been studied for the treatment of acne based on its anti\u2010inflammatory\/antioxidant properties. This systematic review and meta\u2010analysis aimed to examine the effects of GTE on acne. Electronic databases, including PubMed, Embase, and the Cochrane Library were systematically searched up to August 2019. The effect size of acne lesion counts is presented as mean differences and 95% confidence intervals (CIs). Five randomized\u2010controlled studies were included in the meta\u2010analysis (<jats:italic>N<\/jats:italic>; experimental = 125, control = 122). GTE significantly reduced the number of inflammatory lesions (\u22129.38; 95% CI: \u221214.13 to \u22124.63). In subgroup analysis, topical GTE application significantly reduced the inflammatory lesion counts (\u221211.39; 95% CI: \u221215.91 to \u22126.86) whereas oral GTE intake showed minimal effect (\u22121.40; 95% CI: \u22122.50 to \u22120.30). Although GTE did not significantly reduce the number of non\u2010inflammatory lesions (\u221221.65; 95% CI: \u221247.52 to 4.22), when stratified by the route of admission, non\u2010inflammatory acne lesions were significantly reduced by topical GTE application (\u221232.44; 95% CI: \u221239.27 to \u221225.62) but not with oral GTE administration (0.20; 95% CI: 0.00 to 0.40). This systematic review and meta\u2010analysis suggest that topical GTE application is beneficial for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects. Further high\u2010quality clinical trials are warranted.<\/jats:p>","DOI":"10.1002\/ptr.6809","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T20:11:50Z","timestamp":1598559110000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The effects of green tea on acne vulgaris: A systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-645X","authenticated-orcid":false,"given":"Sooyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo I.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Soonchunhyang University Seoul Hospital, Sooonchunhyang University Medical College  Seoul South Korea"},{"name":"Urological Biomedicine Research Institute Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon K.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.380"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01255.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2001.tb00105.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.12.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2011.640311"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5977"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.112919"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"358","article-title":"The efficacy of topical 2% green tea lotion in mild\u2010to\u2010moderate acne vulgaris","volume":"8","author":"Elsaie M. 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