{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:30:12Z","timestamp":1787661012763,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The increased survival rate of stroke patients has led to the higher incidences of post\u2010stroke depression. Carnosic acid has the ability to cross blood brain barrier with good neuro\u2010modulatory actions. Recently, inclined level of fibroblast growth factor 9 (FGF9) in the postmortem brain of the depressed patients was noted. Therefore, in the present study, the effect of carnosic acid on post\u2010stroke depression\u2010like behavior, and the expression of FGF9 were evaluated. After 3\u2009weeks of middle carotid artery occlusion in Sprague Dawley rats, carnosic acid (20 and 40\u2009mg\/kg) was administered for 2\u2009weeks. Sucrose preference test, forced swimming test, and open field test were performed and hippocampi were analyzed for FGF9 and FGFR\u20103. In comparison to post\u2010stroke depressed rats, carnosic acid increased the sucrose preference, and reduced the immobility time of the rats by ~2\u00d7. The speed and distance\u2010covered were also increased. At 40\u2009mg\/kg, FGF9 was reduced by ~3\u00d7 while FGFR\u20103\/Actin was increased by ~1.5\u00d7. Altogether results suggest anti\u2010depressant\u2010like activity of carnosic acid in post\u2010stroke depressed rats with decreased expression of hippocampal FGF9.<\/jats:p>","DOI":"10.1002\/ptr.6810","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T02:23:59Z","timestamp":1597199039000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Carnosic acid ameliorates depressive\u2010like symptoms along with the modulation of <scp>FGF9<\/scp> in the hippocampus of middle carotid artery occlusion\u2010induced Sprague Dawley rats"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-4405","authenticated-orcid":false,"given":"Mudassar","family":"Azhar","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs &amp; Hunan Provincial Research Center for Safety Evaluation of Drugs  Changsha China"},{"name":"Dr. Panjwani Center for Chemical and Biological Sciences, International Center for Chemical and Biological Center University of Karachi  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guirong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs &amp; 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