{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:59:46Z","timestamp":1792738786377,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is associated with insulin resistance and dyslipidemia. Pomegranate juice is a rich source of polyphenols that may improve blood pressure, lipid profile, and other risk factors of cardiovascular diseases (CVDs). No study has examined the effects of pomegranate juice consumption on the clinical outcomes of PCOS. This study aimed to examine the effects of concentrated pomegranate juice (CPJ) consumption on risk factors of CVDs in women with PCOS. In this randomized clinical trial, 44 PCOS women with an age range of 18\u201340\u2009years and body mass index (BMI) of \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> were recruited. They were randomly allocated to the CPJ (<jats:italic>n<\/jats:italic> = 22) and control (<jats:italic>n<\/jats:italic> = 22) groups, and followed for 8\u2009weeks. Anthropometric measures, blood pressure, and biochemical parameters were measured at baseline and at the end of the trial. Compared with the control group, CPJ consumption significantly reduced systolic (\u22129.77\u2009\u00b1\u20091.46 vs. \u22121.18\u2009\u00b1\u20091.46\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and diastolic (\u22123.87\u2009\u00b1\u20091.36 vs. 0.30\u2009\u00b1\u20091.36\u2009mmHg, <jats:italic>p<\/jats:italic> = .05) blood pressure, serum triglyceride (TG) levels (\u22127.82\u2009\u00b1\u20096.32 vs. 16.63\u2009\u00b1\u20096.32\u2009mg\/dl, <jats:italic>p<\/jats:italic> = .01), TG\/high\u2010density lipoprotein\u2010cholesterol (HDL\u2010C) ratio (\u22120.39\u2009\u00b1\u20090.24 vs. 0.66\u2009\u00b1\u20090.24, <jats:italic>p<\/jats:italic> = .007), and increased serum concentrations of low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C) (6.03\u2009\u00b1\u20092.47 vs. \u22121.98\u2009\u00b1\u20092.47\u2009mg\/dl, <jats:italic>p<\/jats:italic> = .04) and HDL\u2010C (1.93\u2009\u00b1\u20091.10 vs. \u22121.78\u2009\u00b1\u20091.10 mg\/dl, <jats:italic>p<\/jats:italic> = .03). These findings were obtained after taking baseline measurements and potential confounders into account. No adverse event or complication was reported due to CPJ consumption throughout the study. We found that CPJ consumption has a beneficial effect on blood pressure, serum concentrations of TG and HDL\u2010C, and TG\/HDL\u2010C ratio in women with PCOS. However, this juice could increase serum LDL\u2010C levels in these patients. This trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.irct.ir\">www.irct.ir<\/jats:ext-link> as IRCT20191109045383N1.<\/jats:p>","DOI":"10.1002\/ptr.6820","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:22:59Z","timestamp":1596846179000},"page":"442-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-7481","authenticated-orcid":false,"given":"Maryam","family":"Abedini","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatav","family":"Ghasemi\u2010Tehrani","sequence":"additional","affiliation":[{"name":"Department of Reproductive, Shahid Beheshti Fertility and Infertility Clinic Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J.","family":"Tarrahi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Amani","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2019.01.002"},{"issue":"6","key":"e_1_2_8_3_1","first-page":"326","article-title":"Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals","volume":"9","author":"Asgary S.","year":"2013","journal-title":"ARYA Atherosclerosis"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4977"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00412-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1062"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.08.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.01.006"},{"issue":"4","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1590\/S1807-59322008000400003","article-title":"High ratio of triglycerides to HDL\u2010cholesterol predicts extensive coronary disease","volume":"63","author":"da Luz P. 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