{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:41:38Z","timestamp":1790700098738,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    The aim of this study was to evaluate the efficacy of sour tea supplementation in patients with nonalcoholic fatty liver disease (NAFLD). Seventy NAFLD patients were enrolled in this randomized, double\u2010blind, placebo\u2010controlled clinical trial. Participants received sour tea in the form of a 450\u2009mg capsule or a placebo capsule daily for 8\u2009weeks. Anthropometric indices, liver enzymes, lipid profile, blood pressure, and antioxidant status were evaluated at the baseline and at the end of the study. Sixty\u2010one participants completed the study. After 8\u2009weeks, sour tea administration significantly decreased serum triglyceride (TG) (\n                    <jats:italic>p<\/jats:italic>\n                    = .03), alanine aminotransferase (ALT) (\n                    <jats:italic>p<\/jats:italic>\n                    = .01), and aspartate aminotransferase (AST) (\n                    <jats:italic>p<\/jats:italic>\n                    = .004) levels compared with the placebo. In addition, sour tea supplementation resulted in a significant reduction in systolic blood pressure (SBP) (\n                    <jats:italic>p<\/jats:italic>\n                    = .03) and diastolic blood pressure (DBP) (\n                    <jats:italic>p<\/jats:italic>\n                    = .04), and a significant increase in serum total antioxidant capacity (TAC) levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u02c2 .001) compared with the placebo. However, no significant changes in anthropometric measures, total cholesterol (TC), low\u2010density lipoprotein cholesterol (LDL\u2010c), and high\u2010density lipoprotein cholesterol (HDL\u2010c) levels were observed after sour tea supplementation compared with the placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). Sour tea supplementation may be effective in improving serum TG, liver enzymes, and blood pressure in patients diagnosed with NAFLD. Further studies are needed to address the exact mechanism of action of these effects.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6826","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T09:57:38Z","timestamp":1600941458000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effect of sour tea supplementation on liver enzymes, lipid profile, blood pressure, and antioxidant status in patients with non\u2010alcoholic fatty liver disease: A double\u2010blind randomized controlled clinical trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2221-9399","authenticated-orcid":false,"given":"Fatemeh","family":"Izadi","sequence":"first","affiliation":[{"name":"Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhosein","family":"Farrokhzad","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Tamizifar","sequence":"additional","affiliation":[{"name":"Isfahan Gastroenterology and Hepatology Research Center (lGHRC) Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Tarrahi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Entezari","sequence":"additional","affiliation":[{"name":"Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-019-00475-2"},{"issue":"5","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ptr.1628","article-title":"Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: A review","volume":"19","author":"Ali B. 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