{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:27:17Z","timestamp":1780586837764,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Facial pore enlargement is considered a significant esthetic and health concern in skincare cosmetics. The pores fulfill the critical function of keeping the skin surface hydrated and protected against microbial infections. The hyperseborrhea, the stress factors, and the hormonal triggers can cause pore size enlargement, causing higher susceptibility of the skin to microbe aggressions and inflammatory reactions. Thus, reducing excessive sebum production and keeping functional pores are two of the most requested activities in skincare cosmetics. A <jats:italic>Cirsium eriophorum<\/jats:italic> cell culture extract was investigated for its role in sebum regulation, stratum corneum desquamation, and anti\u2010inflammation. The extract was able to regulate essential markers associated with sebum secretion and pore enlargements, such as the enzyme 5\u03b1\u2010reductase, which plays a central role in sebum production, and the trypsin\u2010like serine protease Kallikrein 5, which promotes skin exfoliation and antimicrobial response. Moreover, the extract showed a sebum\u2010normalizing and pore refining activity in individuals having seborrheic or acne\u2010prone skins, suggesting a role of the <jats:italic>C. eriophorum<\/jats:italic> extract in rebalancing altered skin conditions responsible for pore enlargement.<\/jats:p>","DOI":"10.1002\/ptr.6832","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T20:11:50Z","timestamp":1598559110000},"page":"530-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Plant cell culture extract of <i>Cirsium eriophorum<\/i> with skin pore refiner activity by modulating sebum production and inflammatory response"],"prefix":"10.1002","volume":"35","author":[{"given":"Sonia","family":"Laneri","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-1431","authenticated-orcid":false,"given":"Irene","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Tito","sequence":"additional","affiliation":[{"name":"Arterra Bioscience SpA  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritamaria","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marida","family":"Bimonte","sequence":"additional","affiliation":[{"name":"Arterra Bioscience SpA  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Tortora","sequence":"additional","affiliation":[{"name":"Arterra Bioscience SpA  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zappelli","sequence":"additional","affiliation":[{"name":"Vitalab srl  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Angelillo","sequence":"additional","affiliation":[{"name":"Vitalab srl  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Colucci","sequence":"additional","affiliation":[{"name":"Arterra Bioscience SpA  Naples Italy"},{"name":"Vitalab srl  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-2761","authenticated-orcid":false,"given":"Fabio","family":"Apone","sequence":"additional","affiliation":[{"name":"Arterra Bioscience SpA  Naples Italy"},{"name":"Vitalab srl  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.209895"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119312994.apr0679"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5560\/znc.2014-0071"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112729"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5786"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7932019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6494"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"33","article-title":"Enlarged facial pores: An update on treatments","volume":"98","author":"Dong J. 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