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Glycyrrhizin (GZ) is a promising agent against SARS\u2010CoV\u20102 as its antiviral activity against SARS\u2010CoV has already been confirmed. It is worthwhile to extrapolate from its proven therapeutic effects as there is a high similarity in the structure and genome of SARS\u2010CoV and SARS\u2010CoV\u20102. There are many possible mechanisms through which GZ acts against viruses: increasing nitrous oxide production in macrophages, affecting transcription factors and cellular signalling pathways, directly altering the viral lipid\u2010bilayer membrane, and binding to the ACE2 receptor. In this review, we discuss the possible use of GZ in the COVID\u201019 setting, where topical administration appears to be promising, with the nasal and oral cavity notably being the potent location in terms of viral load. The most recently published papers on the distribution of ACE2 in the human body and documented binding of GZ to this receptor, as well as its antiviral activity, suggest that GZ can be used as a therapeutic for COVID\u201019 and as a preventive agent against SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1002\/ptr.6852","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T07:54:50Z","timestamp":1600156490000},"page":"629-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Glycyrrhizin: An old weapon against a novel coronavirus"],"prefix":"10.1002","volume":"35","author":[{"given":"Julian","family":"Chrzanowski","sequence":"first","affiliation":[{"name":"Chair and Department of Biochemistry Medical University of Warsaw, Banacha 1  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6928-4561","authenticated-orcid":false,"given":"Alicja","family":"Chrzanowska","sequence":"additional","affiliation":[{"name":"Chair and Department of Biochemistry Medical University of Warsaw, Banacha 1  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-0384","authenticated-orcid":false,"given":"Wojciech","family":"Grabo\u0144","sequence":"additional","affiliation":[{"name":"Chair and Department of Biochemistry Medical University of Warsaw, Banacha 1  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"AAO\u2010HNS: Anosmia Hyposmia and Dysgeusia Symptoms of Coronavirus Disease. 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