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These bioactive compounds can release therapeutic potential abilities via reducing antitumor drugs side effects or directly killing cancer cells, and others also can adjust cancer initiation and progression via regulating microRNAs (miRNAs) expression, and miRNA can regulate protein\u2010coding expression by restraining translation or degrading target mRNA. A mass of research showed that plant\u2010derived bioactive compounds including tanshinones, astragaloside IV, berberine, ginsenosides and matrine can inhibit tumor growth and metastasis by rescuing aberrant miRNAs expression, which has influence on tumor progression, microenvironment and drug resistance in multifarious cancers. This review aims to provide a novel understanding of plant\u2010derived bioactive compounds targeting miRNAs and shed light on their future clinical applications.<\/jats:p>","DOI":"10.1002\/ptr.6883","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T21:13:30Z","timestamp":1601500410000},"page":"1176-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Roles of plant\u2010derived bioactive compounds and related\n                    <scp>microRNAs<\/scp>\n                    in cancer therapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Heng","family":"Zou","sequence":"first","affiliation":[{"name":"Lab for Noncoding RNA &amp; Cancer, School of Life Sciences Shanghai University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[{"name":"Lab for Noncoding RNA &amp; Cancer, School of 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