{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:45:30Z","timestamp":1789839930615,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant number: 81704102"],"award-info":[{"award-number":["Grant number: 81704102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The aim of this study is to systematically evaluate existing evidence of the Chinese herbal formula, Zuogui pill (ZGP), for the treatment of osteoporosis. A systematic literature search was performed in six electronic databases. The authors independently extracted data in pairs and evaluated the risk of bias. A total of 221 articles were identified initially, of which 12 relevant studies were enrolled. The primary outcome was fracture incidence and bone mineral density (BMD) at different sites. Bone metabolism markers, clinical symptoms, quality of life, and adverse events or adverse drug reactions (ADRs) were secondary outcomes. The results showed that ZGP, combined with anti\u2010osteoporosis drugs, significantly increased BMD at the lumbar spine, Ward's area, and total hip. In terms of markers for improved bone metabolism, ZGP plus conventional drugs dramatically improved the levels of alkaline phosphatase, bone Gla protein, bone alkaline phosphatase, and tartrate\u2010resistant acid phosphatase. Gastrointestinal discomfort, dizziness, and fatigue were found in the combined therapy group. Although the results indicate that ZGP is a potential candidate for osteoporosis, evidence remains insufficient. Further rigorously designed and high\u2010quality trials with a larger sample size are warranted to verify the current conclusions.<\/jats:p>","DOI":"10.1002\/ptr.6908","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T22:11:26Z","timestamp":1603318286000},"page":"1754-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["An evaluation of the effects and safety of Zuogui pill for treating osteoporosis: Current evidence for an ancient Chinese herbal formula"],"prefix":"10.1002","volume":"35","author":[{"given":"Jinyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-3066","authenticated-orcid":false,"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Spine Wangjing Hospital, China Academy of Chinese Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Spine Wangjing Hospital, China Academy of Chinese Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Graduate School Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Graduate School Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-9604","authenticated-orcid":false,"given":"Xu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Scientific Research Wangjing Hospital, China Academy of Chinese Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu093"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta18110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013936"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.43"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3712-7"},{"issue":"02","key":"e_1_2_8_8_1","first-page":"1","article-title":"Guidelines for diagnosis and treatment of postmenopausal osteoporosis with traditional Chinese medicine (2019)","volume":"32","author":"Chinese Association of Chinese Medicine","year":"2020","journal-title":"The Journal of Traditional Chinese Orthopedics and Traumatology"},{"issue":"45","key":"e_1_2_8_9_1","first-page":"3524","article-title":"Guidelines for diagnosis and treatment of osteoporosis with integrated traditional Chinese and western medicine","volume":"99","author":"Chinese Association of Integrative Medicine","year":"2019","journal-title":"National Medical Journal of China"},{"issue":"32","key":"e_1_2_8_10_1","first-page":"3963","article-title":"Guidelines for the diagnosis and management of primary osteoporosis (2017)","volume":"20","author":"Chinese Medical Association of Osteoporosis and Bone Mineral Research","year":"2017","journal-title":"Chinese General Practice"},{"issue":"2","key":"e_1_2_8_11_1","first-page":"65","article-title":"The clinical study of Zuogui pill combined with alendronate sodium in the treatment of postmenopausal osteoporosis","volume":"11","author":"Han Y. 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