{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:42:03Z","timestamp":1792896123715,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>curcumin consumption may have a protective effect against exercise\u2010induced muscle damage (EIMD) through stabilization of the cell membrane via inhibition of free radical formation. Evidence supporting a protective role of curcumin after physical activity induced muscle injury in humans, however, it is inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline, Scopus, and Google scholar were systematically searched up to May 2020. The Cochrane Collaboration tool for assessing the risk of bias was used for assessing the quality of studies. Random effects model, weighted mean difference (WMD), and 95% confidence interval (CI) were used for estimating the overall effect. Between\u2010study heterogeneity was assessed using the chi\u2010squared and I<jats:sup>2<\/jats:sup>statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed a significant effect of curcumin supplementation on reducing creatine kinase (CK) (weighted mean difference [WMD] = \u221248.54\u2009IU.L<jats:sup>\u22121<\/jats:sup>; 95% CI: \u221280.667, \u221216.420;<jats:italic>p<\/jats:italic>=\u2009.003) and muscle soreness index decrease (WMD = \u22120.476; 95% CI: \u22120.750, \u22120.202;<jats:italic>p<\/jats:italic>=\u2009.001). Moreover, a subgroup analysis resulted in a significant decrease in CK concentrations and muscle soreness index, according to follow\u2010ups after exercise, dose of curcumin, duration of studies, exercise type, train status and study design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current evidence revealed a efficacy of curcumin in reducing CK serum levels and muscle soreness index among adults. Therefore, curcumin may be known as a priority EIMD recovery agent in interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ptr.6912","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T08:37:47Z","timestamp":1605083867000},"page":"1768-1781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The effect of curcumin supplementation on recovery following<scp>exercise\u2010induced<\/scp>muscle damage and delayed\u2010onset muscle soreness: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"35","author":[{"given":"Wang","family":"Fang","sequence":"first","affiliation":[{"name":"Henan University of Technology Sports Institute Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-5938","authenticated-orcid":false,"given":"Yasaman","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.09.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2016-0223"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4086-3.00038-2"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"1","article-title":"Effect of curcumin supplementation on exercise\u2010induced oxidative stress, inflammation, muscle damage, and muscle soreness","volume":"17","author":"Basham S. 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