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This study was designed to elevate the effect of crocin administration on withdrawal syndrome, craving, and cognitive function in subjects under MMT programs. It was a clinical trial that was conducted among 60 patients referred to Soltan Mirahmad Clinic for addict patients in Kashan, Iran. The patients were allocated to two groups including placebo and intervention groups. The intervention group received 30\u2009mg\/day crocin (<jats:italic>n<\/jats:italic> = 30) and placebo (<jats:italic>n<\/jats:italic> = 30) once a day, in 12\u2009weeks. Withdrawal syndrome, craving, and cognitive function parameters were measured before and after the intervention in subjects under MMT programs. Compared with the placebo group, crocin resulted in a significant improvement in craving score (<jats:italic>p<\/jats:italic> = .03), and withdrawal symptoms score (<jats:italic>p<\/jats:italic> = .01) in the intervention group. In addition, crocin supplementation did not affect cognitive function parameters (e.g., TMT, FAS test, and DGSP score). Overall, crocin supplementation for 12\u2009weeks to patients under MMT programs had beneficial effects on craving and withdrawal symptoms score, but did not affect the cognitive function parameters.<\/jats:p>","DOI":"10.1002\/ptr.6913","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T05:53:50Z","timestamp":1603173230000},"page":"1486-1494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment"],"prefix":"10.1002","volume":"35","author":[{"given":"Samira","family":"Abbaszadeh\u2010Mashkani","sequence":"first","affiliation":[{"name":"Trauma Nursing Research Center, Faculty of Nursing and Midwifery Kashan University of Medical Sciences  Kashan 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