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In the last years, the emerging evidence about the role of the endogenous gasotransmitter hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) in the pathogenesis and progression of T2DM led to increasing interest in the pharmacological modulation of endogenous \u201cH<jats:sub>2<\/jats:sub>S\u2010system\u201d. Indeed, H<jats:sub>2<\/jats:sub>S directly contributes to the homeostatic maintenance of blood glucose levels; moreover, it improves impaired angiogenesis and endothelial dysfunction under hyperglycemic conditions. Moreover, H<jats:sub>2<\/jats:sub>S promotes significant antioxidant, anti\u2010inflammatory, and antiapoptotic effects, thus preventing hyperglycemia\u2010induced vascular damage, diabetic nephropathy, and cardiomyopathy. Therefore, H<jats:sub>2<\/jats:sub>S\u2010releasing molecules represent a promising strategy in both clinical management of T2DM and prevention of macro\u2010 and micro\u2010vascular complications associated to hyperglycemia. Recently, growing attention has been focused on dietary organosulfur compounds. Among them, garlic polysulfides and isothiocyanates deriving from<jats:italic>Brassicaceae<\/jats:italic>have been recognized as H<jats:sub>2<\/jats:sub>S\u2010donors of great pharmacological and nutraceutical interest. Therefore, a better understanding of the therapeutic potential of naturally occurring H<jats:sub>2<\/jats:sub>S\u2010donors may pave the way to a more rational use of these nutraceuticals in the modulation of H<jats:sub>2<\/jats:sub>S homeostasis in T2DM.<\/jats:p>","DOI":"10.1002\/ptr.6923","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T10:31:54Z","timestamp":1603967514000},"page":"1817-1846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pharmacological modulation of the hydrogen sulfide (<scp>H<sub>2<\/sub>S<\/scp>) system by dietary<scp>H<sub>2<\/sub>S<\/scp>\u2010donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus"],"prefix":"10.1002","volume":"35","author":[{"given":"Eugenia","family":"Piragine","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1441-5421","authenticated-orcid":false,"given":"Vincenzo","family":"Calderone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pisa Pisa Italy"},{"name":"Interdepartmental Research Center Nutrafood \u201cNutraceuticals and Food for Health\u201d University of Pisa Pisa Italy"},{"name":"Interdepartmental Research Centre of Ageing Biology and Pathology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2017.07.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3923\/jas.2019.413.420"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.07.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.643365"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524053766004"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"86","article-title":"A comparative study on hypoglycemic properties, lipid profile and bioactive components of hydro\u2010alcoholic extracts of cooked and raw Brassica napus","volume":"5","author":"Akbari F.","year":"2016","journal-title":"Journal of Nephropharmacology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0184"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11491116"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.955S"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1295"},{"issue":"8","key":"e_1_2_8_12_1","first-page":"696","article-title":"Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) 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