{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:46:06Z","timestamp":1770547566214,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Ischemic stroke is the most prevalent stroke condition in the world resulted in either a transient ischemic attack or long\u2010lasting neurological problems due to the interrupted or reduced blood flow to the brain. <jats:italic>Antrodia camphorata<\/jats:italic> is a well\u2010known medicinal mushroom native to Taiwan and is familiar due to its medicinal effects. The current study investigated the protective effect of <jats:italic>A. camphorata<\/jats:italic>\u2010alcohol extracts (AC\u2010AE) against cobalt (II) chloride (CoCl<jats:sub>2<\/jats:sub>)\u2010induced oxidative stress in vitro and ischemia\/reperfusion\u2010induced brain injury in vivo. The rats were pre\u2010treated with AC\u2010AE for 4\u2009weeks. Our results showed that AC\u2010AE reduced cell damage and decreased reactive oxygen species (ROS) production in C6 and PC12 cells under CoCl<jats:sub>2<\/jats:sub>\u2010induced hypoxic condition. AC\u2010AE doses (385, 770, 1,540\u2009mg\/kg\/day, 4\u2009weeks) increased nuclear factor erythroid 2\u2013related factor 2 (Nrf2) and heme oxygenase\u20101 (HO\u20101) mRNA expressions and decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102) mRNA expressions in Sprague Dawley rat. Besides, it decreased stroke infarct size and increased the level of antioxidants in both brain and serum. Furthermore, it reduced the formation of malondialdehyde (MDA) after ischemia\/reperfusion (I\/R). Our results suggested that AC\u2010AE exerted an effective reduction of ischemia stroke by regulating ROS production.<\/jats:p>","DOI":"10.1002\/ptr.6928","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T07:27:46Z","timestamp":1603697266000},"page":"1609-1620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protective effects of <i>Antrodia camphorata<\/i> extract against hypoxic cell injury and ischemic stroke brain damage"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-6524","authenticated-orcid":false,"given":"Zwe\u2010Ling","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Food Science National Taiwan Ocean University  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Ting","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Food Science National Taiwan Ocean University  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athira","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Food Science National Taiwan Ocean University  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"Chi Hsien Spine Hospital  Kaohsiung Taiwan"},{"name":"Department of Neurological Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Miao","sequence":"additional","affiliation":[{"name":"Teagasc Food Research Centre  Fermoy Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Ling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Food Science National Taiwan Ocean University  Keelung City Taiwan"},{"name":"Teagasc Food Research Centre  Fermoy Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tsou","sequence":"additional","affiliation":[{"name":"Department of Food Science National Taiwan Ocean University  Keelung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180717101104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf063484c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0581263"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1010-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4147320"},{"issue":"6","key":"e_1_2_7_9_1","first-page":"480","article-title":"Acute ischemic stroke: Current status and future directions","volume":"113","author":"French B. 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