{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:45Z","timestamp":1786978425182,"version":"build-2736575974"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["99\u201001\u2010106\u201022309"],"award-info":[{"award-number":["99\u201001\u2010106\u201022309"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    Arisen in China, COVID\u201019 (SARS\u2010CoV\u2010II) is a novel coronavirus that has been expanding fast worldwide. Till now, no definite remedial drug or vaccine has been identified for COVID\u201019 treatment. Still, for a majority of infected patients, supportive therapy is the cornerstone of the management plan. To the importance of managing the COVID\u201019 pandemic, this article proposed to collecting capable medicinal plants and bioactive components in both treat and supportive therapy of this novel viral infection. Clinical points in the pathogenesis, symptoms, and complications of COVID\u201019 were considered. The effective plants and bioactives that may play a role in supportive therapy\/management of COVID\u201019 were searched, collected through the \u201cScopus\u201d database and listed in three sections. Numerous medicinal plants such as\n                    <jats:italic>Citrus<\/jats:italic>\n                    Spp.,\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    , and\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    can interference with COVID\u201019 pathogenesis via inhibition of virus replication and entry to its host cells. Also, some anti\u2010inflammatory herbal medicine such as\n                    <jats:italic>Andrographis paniculata<\/jats:italic>\n                    ,\n                    <jats:italic>Citrus<\/jats:italic>\n                    spp., and\n                    <jats:italic>Cuminum cyminum<\/jats:italic>\n                    can relieve fever and cough in COVID\u201019 patients. Medicinal plants such as\n                    <jats:italic>G. glabra<\/jats:italic>\n                    ,\n                    <jats:italic>Thymus vulgaris<\/jats:italic>\n                    ,\n                    <jats:italic>Allium sativum<\/jats:italic>\n                    ,\n                    <jats:italic>Althea officinalis<\/jats:italic>\n                    , and\n                    <jats:italic>Panax ginseng<\/jats:italic>\n                    may modulate the immune system and possess prevention and supportive therapy. However, more clinical data are required to confirm these hypotheses.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6936","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T23:58:17Z","timestamp":1604707097000},"page":"1925-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A pharmacology\u2010based comprehensive review on medicinal plants and phytoactive constituents possibly effective in the management of\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-5447","authenticated-orcid":false,"given":"Atefeh","family":"Jalali","sequence":"first","affiliation":[{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy) School of Pharmacy, Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Dabaghian","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2018-6378","authenticated-orcid":false,"given":"Hossein","family":"Akbrialiabad","sequence":"additional","affiliation":[{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Student Research Committee, School of Medicine, Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-2043","authenticated-orcid":false,"given":"Farzaneh","family":"Foroughinia","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-4993","authenticated-orcid":false,"given":"Mohammad M.","family":"Zarshenas","sequence":"additional","affiliation":[{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy) School of Pharmacy, Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Epilepsy Research Center, Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2017.10.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"Adem S. 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