{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:13:10Z","timestamp":1793160790174,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["96"],"award-info":[{"award-number":["96"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double\u2010blind, placebo\u2010controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), received either 80\u2009mg nanocurcumin daily for 12\u2009weeks or placebo. Primary endpoints in this study were serum insulin levels and insulin resistance. Curcumin intake significantly decreased fasting plasma glucose (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.02), insulin (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.01), insulin resistance (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.02), and significantly increased insulin sensitivity (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.008) compared with the placebo. Moreover, curcumin intake led to a significant reduction in total\u2010 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u2009.001), LDL\u2010cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u2009.001), and a significant increase in total antioxidant capacity (TAC) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u2009.001) and total glutathione (GSH) (\n                    <jats:italic>p<\/jats:italic>\n                    =\u2009.01) compared with the placebo. However, there was no significant improvement in wound healing parameters. Overall, our study demonstrated that nanocurcumin intake in patients with DFU resulted in a significant improvement of glycemic control, total\u2010 and LDL\u2010cholesterol, TAC, and GSH but did not affect the indicators of ulcer size.\n                  <\/jats:p>","DOI":"10.1002\/ptr.6957","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T22:38:34Z","timestamp":1605566314000},"page":"2099-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Mehrdad","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Razzaghi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine Kashan University of Medical Sciences  Kashan Iran"},{"name":"Social Determinants of Health Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-8717","authenticated-orcid":false,"given":"Mansooreh","family":"Momen\u2010Heravi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine Kashan University of Medical Sciences  Kashan Iran"},{"name":"Social Determinants of Health Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0606-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107996"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.098616"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"71","article-title":"Diabetic foot infection","volume":"78","author":"Bader M. 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